Petra TÓTH

  ⇨  Team

Trained as a neurobiologist, I have always enjoyed working at the interface of cell biology and neuroscience, and have been an associated professor in cell biology in the “Intracellular membrane traffic in the nervous and neuroendocrine systems” team since 2006.

My research projects focus on the molecular mechanisms that regulate exocytosis, which enables the release of hormones and neurotransmitters, and compensatory endocytosis, which ensures the reuptake of the vesicular membrane. I am particularly interested in the role of membrane lipids and their molecular partners in these fundamental mechanisms.

In a physiological context, I try to decipher the role of Phospholipid Scramblase-1 a protein, involved in the maintenance of membrane asymmetry and crucial for the coupling of exo – endocytosis during neurotransmission.

Exocytosis and secretion can be dysregulated in multiple pathologies. In this context, I am attempting to understand the molecular mechanisms that lead to hypersecretion in neuroendocrine tumors, putting patients’ health at risk. In another pathological context, that is obesity, I’m studying how leptin, a satiety hormone secreted in the periphery, is delivered to neurons in the hypothalamus via microglia. The mechanism of vesicular, intracellular trafficking of leptin through microglia is unknown. Deciphering this mechanism would help us to understand why neurons no longer respond to the “satiety message” conveyed by leptin in obese patients.

I develop and contribute to three principal projects
Responsibility in INCI laboratory
  • Elected member of laboratory council