Functional organisation and light response of retinal clock(s)


  ⇨  Teams  ⇨  Light, vision and brain


Rhythmicity is central to retinal physiology and underlies adaptation of visual function to the changes in light intensity occurring along the 24h day/night cycle.

Rhythmic processes in the retina are controlled by a circadian clock located within the tissue. Our work aims at understanding its molecular and cellular mechanisms, its organization into a network of oscillators and its synchronization with the light/dark cycle.

We also study transcriptional regulations downstream of the clock in order to identify mechanisms driving retinal physiology and, when disturbed, retinal pathology.

Team members

Marie-Paule Felder-Schmittbuhl

Cristina Sandu

Ph. D.
  • Arthur Bergen, UMC Amsterdam
  • Ouria Dkhissi-Benyahya, Institut Cellules Souche et Cerveau, Bron
  • Ségolen Geffray, IRMA, Strasbourg
  • Arturo Ortega, Cinvestav, Mexico
  • Anand Swaroop, NEY, NIH, Bethesda, USA
  • Prapimpun Wongchitrat, Mahidol University, Bangkok, Thailand
Selected publications

Bagchi U, Gegnaw ST, Milićević N, Sandu C, Ten Brink JB, Jongejan A, Hicks D, Moerland PD, Felder-Schmittbuhl MP*, Bergen AA.  Core-clock genes Period 1 and 2 regulate visual cascade and cell cycle components during mouse eye development. Biochim Biophys Acta Gene Regul Mech (2020) 1863:194623.

Milićević N, Ait-Hmyed Hakkari O, Bagchi U, Sandu C, Jongejan A, D. Moerland P, ten Brink JB, Hicks D, Bergen AA, Felder-Schmittbuhl MP Core Circadian Clock Genes Per1 and Per2 regulate the Rhythm in Photoreceptor Outer Segment Phagocytosis Faseb J (2021) 35:e21722.

Gegnaw ST, Sandu C, Mendoza J, Bergen AA, Felder-Schmittbuhl MP. Dark-adapted light response in mice is regulated by a circadian clock located in rod photoreceptors. Exp Eye Res. (2021) 213:108807. doi:10.1016/j.exer.2021.108807.

Bery A, Bagchi U, Bergen AA, Felder-Schmittbuhl MP Circadian clocks, retinogenesis and ocular health in vertebrates: new molecular insights. Dev Biol. (2022) 484 :40-56.