{"id":4780,"date":"2023-03-04T16:38:05","date_gmt":"2023-03-04T15:38:05","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4780"},"modified":"2024-01-24T07:12:20","modified_gmt":"2024-01-24T06:12:20","slug":"modulation-et-plasticite-de-linhibition-spinale","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4780","title":{"rendered":"Modulation et plasticit\u00e9 de l\u2019inhibition spinale"},"content":{"rendered":"\t\t
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Modulation & plasticit\u00e9 de l’inhibition spinale<\/b><\/strong><\/a><\/p>\n

Perrine INQUIMBERT<\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>  ⇨  Syst\u00e8me opio\u00efde, nociception et douleur<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/a>Au sein du r\u00e9seau de la corne dorsale, l\u2019\u00e9quilibre entre l\u2019excitation et l\u2019inhibition joue un r\u00f4le critique dans l\u2019int\u00e9gration des informations nociceptives.<\/p>

Deux des m\u00e9canismes connus pour rompre cet \u00e9quilibre lors du d\u00e9veloppement de douleurs chroniques sont une activation accrue des r\u00e9cepteurs NMDA et une diminution de la transmission synaptique inhibitrice.<\/p>

Bien que ces 2 m\u00e9canismes aient \u00e9t\u00e9 bien \u00e9tudi\u00e9s s\u00e9par\u00e9ment, peu d\u2019informations sont disponibles sur leur interaction.<\/p>

L\u2019objectif de ce projet est d\u2019\u00e9tudier la modulation et la plasticit\u00e9 de la transmission synaptique inhibitrice sous le contr\u00f4le de l\u2019activation des r\u00e9cepteurs NMDA et de comprendre le r\u00f4le de ces processus dans le d\u00e9veloppement et le maintien des douleurs chroniques.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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  ⇨  Les \u00e9quipes  ⇨  Syst\u00e8me opio\u00efde, nociception et douleur Pr\u00e9sentation Au sein du r\u00e9seau de la corne dorsale, l\u2019\u00e9quilibre entre l\u2019excitation et l\u2019inhibition joue un r\u00f4le critique dans l\u2019int\u00e9gration des informations nociceptives. Deux des m\u00e9canismes connus pour rompre cet \u00e9quilibre lors du d\u00e9veloppement de douleurs chroniques sont une activation accrue des r\u00e9cepteurs NMDA et une diminution de la […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4173,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4780","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nModulation et plasticit\u00e9 de l\u2019inhibition spinale - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"Au sein du r\u00e9seau de la corne dorsale, l\u2019\u00e9quilibre entre l\u2019excitation et l\u2019inhibition joue un r\u00f4le critique dans l\u2019int\u00e9gration des informations nociceptives. Deux des m\u00e9canismes connus pour rompre cet \u00e9quilibre lors du d\u00e9veloppement de douleurs chroniques sont une activation accrue des r\u00e9cepteurs NMDA et une diminution de la transmission synaptique inhibitrice\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4780\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Modulation et plasticit\u00e9 de l\u2019inhibition spinale - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"Au sein du r\u00e9seau de la corne dorsale, l\u2019\u00e9quilibre entre l\u2019excitation et l\u2019inhibition joue un r\u00f4le critique dans l\u2019int\u00e9gration des informations nociceptives. 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