{"id":4724,"date":"2023-03-03T17:33:59","date_gmt":"2023-03-03T16:33:59","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4724"},"modified":"2026-03-08T11:22:31","modified_gmt":"2026-03-08T10:22:31","slug":"lipides-et-fusion-membranaire","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4724","title":{"rendered":"Sites de contact membranaire et exocytose r\u00e9gul\u00e9e"},"content":{"rendered":"\t\t
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R\u00f4le des sites de contact membranaire dans la dynamique du calcium et des lipides dans l’exocytose r\u00e9gul\u00e9e<\/strong><\/a><\/p>\n

Sylvette CHASSEROT-GOLAZ, Nicolas VITALE<\/span><\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>  ⇨  Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"L\u2019exocytose r\u00e9gul\u00e9e est un processus complexe qui permet la lib\u00e9ration de mol\u00e9cules informatives stock\u00e9es au sein de v\u00e9sicules d\u00e9di\u00e9es afin de permettre la communication entre cellules dans des organismes pluricellulaires. Ce processus qui d\u00e9bute par la gen\u00e8se des v\u00e9sicules se poursuit par leur transport avant d\u2019aboutir \u00e0 leur arrimage \u00e0 la membrane plasmique puis leur fusion en r\u00e9ponse \u00e0 une \u00e9l\u00e9vation du calcium cytosolique permettant la lib\u00e9ration de leur contenu \u00e0 l\u2019ext\u00e9rieur de la cellule et se termine par le recyclage des composants granulaire par endocytose compensatrice. De nombreuses prot\u00e9ines jouant un r\u00f4le cl\u00e9 dans ces processus ont \u00e9t\u00e9 identifi\u00e9 au cours des derni\u00e8res d\u00e9cennies. Bien que ce processus implique des compartiments membranaires sp\u00e9cifiques, le r\u00f4le des lipides, constituants majeurs des membranes et leur dynamique entre ces compartiments, restent bien moins compris.<\/p>

L\u2019objectif de ce projet est de comprendre le r\u00f4le des sites de contact entre le r\u00e9ticulum endoplasmique, les granules de s\u00e9cr\u00e9tion et la membrane plasmique<\/strong> dans la r\u00e9gulation du cycle d\u2019exocytose et d\u2019endocytose. En particulier, nous \u00e9tudions la dynamique du calcium \u00e0 proximit\u00e9 des sites d\u2019exocytose et la contribution des diff\u00e9rentes formes d\u2019acide phosphatidique (PA) au cours des diff\u00e9rentes \u00e9tapes de l\u2019exocytose et leur dynamique au sein de ces sites de contact entre organelles.\u00a0<\/p>

Pour r\u00e9pondre \u00e0 ces questions, nous utilisons une boite \u00e0 outils mol\u00e9culaires d\u00e9di\u00e9e \u00e0 l\u2019\u00e9tude du PA<\/strong> qui se base sur des approches optog\u00e9n\u00e9tiques et sur l\u2019utilisation de nouvelles formes de PA de synth\u00e8se activable \u00e0 la demande sur la base de la chimie click.<\/p>

\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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M<\/b>embres de l'\u00e9quipe<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"sylvette\"<\/figure>

Sylvette Chasserot-Golaz<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Emeline\"<\/a><\/figure>

Emeline Tanguy<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Nico\"<\/a><\/figure>

Nicolas Vitale<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Stef\"<\/a><\/figure>

St\u00e9phane Gasman<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Alex-400\"<\/a><\/figure>

Alexander Wolf<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"AMH\"<\/a><\/figure>

Anne-Marie Haeberl\u00e9<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\"claudine-boissier-90x110\"<\/figure>

Claudine Boissier<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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\"AvatarFemme-319x320\"<\/a><\/figure>

Sebahat Ozkan<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Pr Mait\u00e9 Montero<\/strong> : DC2N laboratory, Rouen
Pr Pierre-Yves Renard<\/strong> : CARMEN laboratory, Rouen
Dr Johann B\u00f6hm<\/strong> : IGBMC, Strasbourg
Dr Guillaume Drin<\/strong> : IPMC, Valbonne
Dr Oussama El Far<\/strong> : UNIS Laboratory, Marseille
Dr Franck Delavoie<\/strong> : University of Toulouse III, Toulouse<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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– Streit L, Delavoie F, Wolf A, Royer C, Haeberl\u00e9 AM, Hugel S, Gasman S, Vitale N, Chasserot-Golaz S. Endoplasmic reticulum membrane contact sites coordinate exocytic site assembly and activity in neuroendocrine cells. BioRxiv<\/strong> 2026 https:\/\/doi.org\/10.64898\/2026.02.04.703764<\/p>

– Schlichter A, Wolf A, Ferrand T, Cocq A, Riachy L, Vertueux S, Beauvais B, Courvalet M, Henry PJ, Tanguy E, Gonzales L, Ferlet R, Laguerre F, Decraene C, Pellissier A, Sebban M, Sabot C, Jeandel L, Cianf\u00e9rani S, Strub JM, B\u00e9nard M, Flon V, Peulon-Agasse V, Cardinael P, Ory S, Gasman S, Renard PY, Montero-Hadjadje M, Vitale N, Balieu S. Designing New Natural-Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research. Angew Chem Int Ed Engl<\/strong> 2025 Jul 8:e202510412.<\/p>

– Tanguy E, Cost\u00e9 de Bagneaux P, Kassas N, Ammar MR, Wang Q, Haeberl\u00e9 AM, Raherindratsara J, Fouillen L, Renard PY, Montero-Hadjadje M, Chasserot-Golaz S, Ory S, Gasman S, Bader MF and Vitale N. Mono- and poly-unsaturated phosphatidic acid regulate distinct steps of regulated exocytosis in neuroendocrine cells. Cell Reports<\/strong> 2020, 32(7):108026.<\/p>

– Kassas N, Tanguy E, Thahouly T, Fouillen L, Heintz D, Chasserot-Golaz S, Bader MF, Grant NJ, Vitale N. Comparative characterization of phosphatidic acid sensors and their localization during frustrated phagocytosis. J Biol Chem<\/strong> 2017, 292: 4266-4279<\/p>

– Gabel M, Delavoie F, Demais V, Royer C, Bailly Y, Vitale N, Bader MF, Chasserot-Golaz S. Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.
J Cell Biol <\/strong>2015 Aug 31;210(5):785-800<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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C<\/b>ommuniqu\u00e9s de Presse<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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CNRS: Quand les lipides r\u00e9v\u00e8lent leurs secrets<\/a><\/p>

Actualit\u00e9s INSERM: Le r\u00f4le de l\u2019acide phosphatidique dans la s\u00e9cr\u00e9tion hormonale par les cellules neuroendocrines<\/a><\/span><\/p>

Avanti Polar Lipids Research Spotlight: Mono- and Poly-unsaturated Phosphatidic Acid Regulates Distinct Steps of Regulated Exocytoses in Neuroendocrine Cells<\/a><\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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  ⇨  Les \u00e9quipes  ⇨  Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines Pr\u00e9sentation L\u2019exocytose r\u00e9gul\u00e9e est un processus complexe qui permet la lib\u00e9ration de mol\u00e9cules informatives stock\u00e9es au sein de v\u00e9sicules d\u00e9di\u00e9es afin de permettre la communication entre cellules dans des organismes pluricellulaires. Ce processus qui d\u00e9bute par la gen\u00e8se des v\u00e9sicules se poursuit par leur transport […]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":4170,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4724","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nSites de contact membranaire et exocytose r\u00e9gul\u00e9e - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"L\u2019exocytose permet la lib\u00e9ration de mol\u00e9cules informatives contenues dans des v\u00e9sicules de s\u00e9cr\u00e9tion \u00e0 l\u2019ext\u00e9rieur de la cellule. Bien que ce processus implique des compartiments membranaires sp\u00e9cifiques, le r\u00f4le des lipides, constituants majeurs des membranes, reste peu compris\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4724\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sites de contact membranaire et exocytose r\u00e9gul\u00e9e - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"L\u2019exocytose permet la lib\u00e9ration de mol\u00e9cules informatives contenues dans des v\u00e9sicules de s\u00e9cr\u00e9tion \u00e0 l\u2019ext\u00e9rieur de la cellule. Bien que ce processus implique des compartiments membranaires sp\u00e9cifiques, le r\u00f4le des lipides, constituants majeurs des membranes, reste peu compris\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4724\" \/>\n<meta property=\"og:site_name\" content=\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-08T10:22:31+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-TMISNN-1000x70-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@incicnrs\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4724\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4724\",\"name\":\"Sites de contact membranaire et exocytose r\u00e9gul\u00e9e - Institut des Neurosciences Cellulaires et Int\u00e9gratives\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4724#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4724#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/fleche-bas-TMISNN-1000x70-1.png\",\"datePublished\":\"2023-03-03T16:33:59+00:00\",\"dateModified\":\"2026-03-08T10:22:31+00:00\",\"description\":\"L\u2019exocytose permet la lib\u00e9ration de mol\u00e9cules informatives contenues dans des v\u00e9sicules de s\u00e9cr\u00e9tion \u00e0 l\u2019ext\u00e9rieur de la cellule. 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