{"id":4722,"date":"2023-03-03T17:33:29","date_gmt":"2023-03-03T16:33:29","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4722"},"modified":"2025-08-26T18:01:28","modified_gmt":"2025-08-26T16:01:28","slug":"formation-des-sites-dendocytose","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4722","title":{"rendered":"Formation des sites d’endocytose"},"content":{"rendered":"\t\t
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Formation des sites d’exocytose<\/strong><\/a><\/p>\n

Sylvette CHASSEROT-GOLAZ<\/span><\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>  ⇨  Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/a>L\u2019objectif de ce projet est de montrer que les sites d\u2019exocytose sont des plateformes lipidiques constituant des sites d\u2019assemblage des machineries mol\u00e9culaires impliqu\u00e9es dans la s\u00e9cr\u00e9tion neuroendocrine.<\/p>

Dans ce but la composition de ces plateformes et leurs m\u00e9canismes de formation impliquant l\u2019Annexine A2 et l\u2019actine sont \u00e9tudi\u00e9s.<\/p>

La tomographie \u00e9lectronique a mis en \u00e9vidence diff\u00e9rentes structures d\u2019actine associ\u00e9es aux granules ancr\u00e9s \u00e0 la membrane plasmique. Nous \u00e9tudions le r\u00f4le de ces diff\u00e9rentes structures d\u2019actine et leur origine.<\/p>

L\u2019importance fonctionnelle des contacts entre le r\u00e9ticulum endoplasmique et la membrane plasmique \u00e9merge en particulier dans le contexte de l\u2019influence de l\u2019organisation de la membrane plasmique sur des fonctions cellulaires sp\u00e9cifiques.<\/p>

La derni\u00e8re partie du projet est consacr\u00e9e \u00e0 la caract\u00e9risation des contacts membranaires du r\u00e9ticulum endoplasmique au niveau des sites d\u2019exocytose.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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M<\/b>embres de l'\u00e9quipe<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/figure>

Sylvette Chasserot-Golaz<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/figure>

Claudine Boissier<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/figure>

Anne-Marie Haeberl\u00e9<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Franck Delavoie, Laboratoire de Biologie Mol\u00e9culaire Eucaryote, UMR5099 CNRS-Universit\u00e9 de Toulouse III Paul Sabatier<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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P<\/b>ublications choisies<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Delavoie F, Royer C, Gasman S, Vitale N, Chasserot-Golaz S\u00a0 (2021)<\/span> <\/span>Transmission electron microscopy and tomography on plasma membrane sheets to study secretory docking.
Methods Mol Biol<\/strong> 2233:301-309.
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\u00a0<\/div><\/div><\/div>

Gabel M, Royer C, Thahouly T, Calco V, Gasman S, Bader MF, Vitale N, Chasserot-Golaz S (2020) Annexin A2 Egress during Calcium-Regulated Exocytosis in Neuroendocrine Cells. Cells<\/strong> 9. E2059.<\/p>

Gabel M, Delavoie F, Royer C, Tahouly T, Gasman S, Bader MF, Vitale N, Chasserot-Golaz S (2019) Phosphorylation cycling of Annexin A2 Tyr23 is critical for calcium-regulated exocytosis in neuroendocrine cells. Biochim Biophys Acta Mol Cell Res<\/strong> 1866:1207-1217.<\/p>

Gabel M, Chasserot-Golaz S (2016) Annexin A2, an essential partner of the exocytotic process in chromaffin cells. J Neurochem<\/strong> 137:890-896.<\/p>

Gabel M, Delavoie F, Demais V, Royer C, Bailly Y, Vitale N, Bader MF, Chasserot-Golaz S (2015) Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis. J Cell Biol<\/strong> 210:785-800.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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  ⇨  Les \u00e9quipes  ⇨  Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines Pr\u00e9sentation L\u2019objectif de ce projet est de montrer que les sites d\u2019exocytose sont des plateformes lipidiques constituant des sites d\u2019assemblage des machineries mol\u00e9culaires impliqu\u00e9es dans la s\u00e9cr\u00e9tion neuroendocrine. Dans ce but la composition de ces plateformes et leurs m\u00e9canismes de formation impliquant l\u2019Annexine A2 et […]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":4170,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4722","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nFormation des sites d'endocytose - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"L\u2019objectif de ce projet est de montrer que les sites d\u2019exocytose sont des plateformes lipidiques constituant des sites d\u2019assemblage des machineries mol\u00e9culaires impliqu\u00e9es dans la s\u00e9cr\u00e9tion neuroendocrine.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4722\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Formation des sites d'endocytose - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"L\u2019objectif de ce projet est de montrer que les sites d\u2019exocytose sont des plateformes lipidiques constituant des sites d\u2019assemblage des machineries mol\u00e9culaires impliqu\u00e9es dans la s\u00e9cr\u00e9tion neuroendocrine.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4722\" \/>\n<meta property=\"og:site_name\" content=\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"article:modified_time\" content=\"2025-08-26T16:01:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-TMISNN-1000x70-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@incicnrs\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"5 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4722\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4722\",\"name\":\"Formation des sites d'endocytose - 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