{"id":4622,"date":"2023-03-03T14:57:29","date_gmt":"2023-03-03T13:57:29","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4622"},"modified":"2024-03-19T07:14:26","modified_gmt":"2024-03-19T06:14:26","slug":"transmission-synaptique-dans-le-cortex-cerebelleux-2","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4622","title":{"rendered":"Codage synaptique de l\u2019information dans le cortex c\u00e9r\u00e9belleux"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4622\" class=\"elementor elementor-4622\">\n\t\t\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-15db6ab elementor-section-full_width elementor-section-content-top elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"15db6ab\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-efe82be\" data-id=\"efe82be\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3fb097b elementor-widget__width-initial elementor-widget elementor-widget-wp-widget-media_image\" data-id=\"3fb097b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-media_image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1092x380-1.png\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1092\" height=\"320\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1092x380-1.png\" class=\"image wp-image-15045  attachment-full size-full\" alt=\"\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1092x380-1.png 1092w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1092x380-1-300x88.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1092x380-1-1024x300.png 1024w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1092x380-1-768x225.png 768w\" sizes=\"(max-width: 1092px) 100vw, 1092px\" \/><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-5b7053e\" data-id=\"5b7053e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7746b2c elementor-widget-mobile__width-inherit elementor-widget elementor-widget-wp-widget-text\" data-id=\"7746b2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"textwidget\"><p><a href=\"#bgn\"><strong class=\"titre-physiologie-reseaux-neuronaux\">Codage synaptique de l&rsquo;information dans le cortex c\u00e9r\u00e9belleux<\/strong><\/a><\/p>\n<p><strong><em>Fr\u00e9d\u00e9ric Doussau, Bernard Poulain &amp; Philippe Isope<\/em><br \/>\n<\/strong><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-432389e elementor-section-full_width elementor-section-content-top elementor-section-height-default elementor-section-height-default\" data-id=\"432389e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-91b661d\" data-id=\"91b661d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3f9dcd7 elementor-widget elementor-widget-image\" data-id=\"3f9dcd7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"70\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1.png\" class=\"attachment-full size-full wp-image-5646\" alt=\"\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1.png 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1-300x21.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1-768x54.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bf04d99 elementor-section-height-min-height elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"bf04d99\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a898ae7\" data-id=\"a898ae7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cd18498 elementor-widget elementor-widget-html\" data-id=\"cd18498\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span id=\"bgn\"><\/span>\n<a href=\"https:\/\/inci.neuro.unistra.fr\/\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/02\/home.png\"><\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/#equipes\">Les \u00e9quipes<\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=2110\">Physiologie des r\u00e9seaux neuronaux<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-d84ee0f elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"d84ee0f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ff1ec52\" data-id=\"ff1ec52\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aba13f6 elementor-widget elementor-widget-heading\" data-id=\"aba13f6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5ff09ae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5ff09ae\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c20953e\" data-id=\"c20953e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eec56d0 elementor-widget elementor-widget-text-editor\" data-id=\"eec56d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8895\" aria-describedby=\"caption-attachment-8895\" style=\"width: 128px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"wp-image-8895\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Frederic.Doussau-214x300-1.jpg\" alt=\"\" width=\"128\" height=\"180\" \/><figcaption id=\"caption-attachment-8895\" class=\"wp-caption-text\"><span class=\"legende\">Fr\u00e9d\u00e9ric Doussau<\/span> (CRHC)<\/figcaption><\/figure><p>L\u2019essentiel de la communication entre les neurones se fait au niveau de connexions sp\u00e9cialis\u00e9es appel\u00e9 synapses. Dans les r\u00e9seaux de neurones, la force de la transmission synaptique est modul\u00e9e en permanence par les activit\u00e9s ant\u00e9rieures et par la fr\u00e9quence \u00e0 laquelle sont \u00e9mis les potentiels d\u2019action. Or, dans le cortex c\u00e9r\u00e9belleux, les informations sensorimotrices sont v\u00e9hicul\u00e9es sous la forme de trains de potentiels d\u2019action \u00e9mis \u00e0 des fr\u00e9quences extr\u00eamement \u00e9lev\u00e9es. La transmission et le codage de ces informations met probablement en jeu des m\u00e9canismes synaptiques sp\u00e9cifiquement adapt\u00e9s aux hautes fr\u00e9quences. Le but de notre projet de recherche est de d\u00e9crypter ces m\u00e9canismes et de comprendre comment il se diversifient en fonction de la nature des modalit\u00e9s sensorielles qui sont trait\u00e9es.<\/p><p>Nous nous int\u00e9ressons plus particuli\u00e8rement aux questions suivantes :<br \/>\u2022 M\u00e9canismes pr\u00e9synaptiques du codage de l\u2019information sensorimotrice par les synapses du cortex c\u00e9r\u00e9belleux<br \/>\u2022 Organisation spatiale et fonctionnelle des connexions synaptiques dans le cortex c\u00e9r\u00e9belleux<\/p><p>Notre travail de recherche repose sur une longue expertise sur les m\u00e9canismes cellulaires et mol\u00e9culaires de la transmission synaptique (trafic des v\u00e9sicules synaptiques, lib\u00e9ration des neurotransmetteurs, plasticit\u00e9 synaptique). Exp\u00e9rimentalement, nous combinons des approches \u00e9lectrophysiologiques \u00e0 des techniques d\u2019optog\u00e9n\u00e9tique et d\u2019imagerie synaptique. A cela est associ\u00e9e une approche histologique pour comprendre l\u2019organisation subcellulaire de plusieurs types synaptiques du cortex c\u00e9r\u00e9belleux. Ces exp\u00e9riences sont notamment men\u00e9es sur des souris transg\u00e9niques dans lesquelles le fonctionnement de la transmission synaptique est perturb\u00e9.<\/p><p>Techniques:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-211faa4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"211faa4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f655658\" data-id=\"f655658\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-eff72ea elementor-widget elementor-widget-text-editor\" data-id=\"eff72ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u2022 Electrophysiologie in vitro (patch-clamp)<br \/>\u2022 Imagerie bi-photonique<br \/>\u2022 Optog\u00e9n\u00e9tique<br \/>\u2022 Transfection in vivo<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-817715a\" data-id=\"817715a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-73aea28 elementor-widget elementor-widget-text-editor\" data-id=\"73aea28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>\u2022 Immunohistochimie<br \/>\u2022 Microscopie confocale<br \/>\u2022 Microscopie par expansion<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-f990cdf elementor-section-content-top elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f990cdf\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a41f2e4\" data-id=\"a41f2e4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-864a940 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"864a940\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-be8a0fc\" data-id=\"be8a0fc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-335a435 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"335a435\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Philippe.Isope-214x300-1-qdgrhbhvvb6eyxysmmx5eqgh8001pegj4cpe6495hc.jpg\" title=\"Philippe.Isope-214&#215;300\" alt=\"Philippe.Isope-214x300\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Philippe Isope (DR1, HDR)<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-13d7200\" data-id=\"13d7200\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ae6a99b elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"ae6a99b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Bernard.Poulain-214x300-1-qdgrhak1oh54nc05s4iiu8p0mm4ohpcss81wouajnk.jpg\" title=\"Bernard.Poulain-214&#215;300\" alt=\"Bernard.Poulain-214x300\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Bernard Poulain (DRCE, HDR)<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c680626 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c680626\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-71722d3\" data-id=\"71722d3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-989e6da elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"989e6da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-30135fd elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"30135fd\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-813194f\" data-id=\"813194f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-634aefe elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"634aefe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>M<\/b>embres<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-07ce6c8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"07ce6c8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-05d269e\" data-id=\"05d269e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c1c00b8 elementor-widget elementor-widget-text-editor\" data-id=\"c1c00b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8952\" aria-describedby=\"caption-attachment-8952\" style=\"width: 143px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8952\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Alice.Basile-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><figcaption id=\"caption-attachment-8952\" class=\"wp-caption-text\"><span class=\"legende\">Alice Basile<\/span> (doctorante)<\/figcaption><\/figure><p>Les fibres moussues v\u00e9hiculent diff\u00e9rentes informations sensorielles et motrices vers le cortex c\u00e9r\u00e9belleux sous la forme de bouff\u00e9es de potentiels d\u2019action \u00e9mises \u00e0 tr\u00e8s hautes fr\u00e9quence. Les terminaisons pr\u00e9synaptiques des fibres moussues sont capables de soutenir la lib\u00e9ration de glutamate \u00e0 ces fr\u00e9quences extr\u00eames ce qui implique une organisation particuli\u00e8re de la machinerie pr\u00e9synaptique de la neurotransmission. Lors de ma th\u00e8se, je cherche \u00e0 caract\u00e9riser les relations structure-fonction de ces terminaisons pr\u00e9synaptiques en me focalisant sur le r\u00f4le du r\u00e9seau d&rsquo;actine et de ses modulateurs telles que les GTPases monom\u00e9riques de la famille Rho. Pour cela, je combine des techniques de transfections cibl\u00e9es des fibres moussue avec une approche histologique (immunohistochimie, microscopie par expansion, microscopie confocale) ou \u00e9lectrophysiologique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a2afd4d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a2afd4d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-eaaf712\" data-id=\"eaaf712\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f43e5e7 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"f43e5e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-2357be4 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"2357be4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8b31cf1\" data-id=\"8b31cf1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4daa6ac elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"4daa6ac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-9e1a5b0 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9e1a5b0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d1968d9\" data-id=\"d1968d9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca1435d elementor-widget elementor-widget-text-editor\" data-id=\"ca1435d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>David Digregorio <em>(Institut Pasteur, Paris)<\/em><\/li><li><a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4170\">St\u00e9phane Gasman<\/a> <em>(INCI, Strasbourg)<\/em><\/li><li>Jean Livet <em>(Institut de la Vision, Paris)<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9449e6c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9449e6c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ea21567\" data-id=\"ea21567\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c069340 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"c069340\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-5bb6041 elementor-section-content-bottom elementor-section-height-min-height elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle elementor-invisible\" data-id=\"5bb6041\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0a331ef\" data-id=\"0a331ef\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b682c91 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"b682c91\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>P<\/b>ublications choisies<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-f609a72 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f609a72\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3fc76e8\" data-id=\"3fc76e8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3448f48 elementor-widget elementor-widget-text-editor\" data-id=\"3448f48\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31081751\" target=\"_blank\" rel=\"noopener\">Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing<\/a>.<br \/>Dorgans K, Demais V, Bailly Y, Poulain B, Isope P, Doussau F.\u00a0<strong>eLife<\/strong>, 2019 May 13;8. pii: e41586.\u00a0PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31081751\">31081751<\/a><\/p><p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28990927\" target=\"_blank\" rel=\"noopener\">Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity<\/a>.<br \/>Doussau F, Schmidt H, Dorgans K, Valera AM, Poulain B, Isope P.\u00a0<strong>eLife<\/strong>, 2017 Oct 9;6. pii: e28935.\u00a0PMID:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28990927\">28990927<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6265884 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6265884\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-11577d5\" data-id=\"11577d5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-91d3a83 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"91d3a83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-6993434 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"6993434\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8605428\" data-id=\"8605428\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-812775e elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"812775e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>F<\/b>inancements<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f0d00fd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f0d00fd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7decb8e\" data-id=\"7decb8e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7fc9895 elementor-widget elementor-widget-image\" data-id=\"7fc9895\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/anr.fr\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/ANR-523x151-1-qdqnpbd9ca8trpbjq74dwtrr0juyqvnsqeo3wst2ww.jpg\" title=\"ANR-523&#215;151\" alt=\"ANR-523x151\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-3040f3f elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3040f3f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wide\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-c106706\" data-id=\"c106706\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1551ed1 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"1551ed1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.cnrs.fr\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-cnrs-90x90-1-qj3v6vvgsnn2tevosfanmdepxw40apnljb3p6fu2o0.gif\" title=\"logo-cnrs-90&#215;90-1\" alt=\"logo-cnrs-90x90-1\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-6c0367c\" data-id=\"6c0367c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e53d803 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"e53d803\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure 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Pr\u00e9sentation L\u2019essentiel de la communication entre les neurones se fait au niveau de connexions sp\u00e9cialis\u00e9es appel\u00e9 synapses. Dans les r\u00e9seaux de neurones, la force de la transmission synaptique est modul\u00e9e en permanence par les activit\u00e9s ant\u00e9rieures et par la fr\u00e9quence \u00e0 laquelle sont \u00e9mis les potentiels d\u2019action. Or, dans le [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":2110,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4622","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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