{"id":4617,"date":"2023-03-03T14:53:56","date_gmt":"2023-03-03T13:53:56","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4617"},"modified":"2024-03-19T07:14:54","modified_gmt":"2024-03-19T06:14:54","slug":"transmission-synaptique-dans-le-cortex-cerebelleux","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4617","title":{"rendered":"Int\u00e9gration sensorimotrice par la voie corticospinale"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4617\" class=\"elementor elementor-4617\">\n\t\t\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-ee1ba4d elementor-section-full_width elementor-section-content-top elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"ee1ba4d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-9feceaa\" data-id=\"9feceaa\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4738909 elementor-widget__width-initial elementor-widget elementor-widget-wp-widget-media_image\" data-id=\"4738909\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-media_image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1915x303-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1915\" height=\"303\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1915x303-1.jpg\" class=\"image wp-image-15058  attachment-full size-full\" alt=\"\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1915x303-1.jpg 1915w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1915x303-1-300x47.jpg 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1915x303-1-1024x162.jpg 1024w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1915x303-1-768x122.jpg 768w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1915x303-1-1536x243.jpg 1536w\" sizes=\"(max-width: 1915px) 100vw, 1915px\" \/><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3fedc79\" data-id=\"3fedc79\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-301f40b elementor-widget-mobile__width-inherit elementor-widget elementor-widget-wp-widget-text\" data-id=\"301f40b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"textwidget\"><p><a href=\"#bgn\"><strong class=\"titre-physiologie-reseaux-neuronaux\">Int\u00e9gration sensiromotrice par la voie corticospinale<\/strong><\/a><\/p>\n<p><strong><em>Matilde Cordero-Erausquin<\/em><br \/>\n<\/strong><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-325b91e elementor-section-full_width elementor-section-content-top elementor-section-height-default elementor-section-height-default\" data-id=\"325b91e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d84408d\" data-id=\"d84408d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b750d34 elementor-widget elementor-widget-image\" data-id=\"b750d34\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"70\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1.png\" class=\"attachment-full size-full wp-image-5646\" alt=\"\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1.png 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1-300x21.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1-768x54.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d6d47f elementor-section-height-min-height elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"2d6d47f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-86cce4b\" data-id=\"86cce4b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4de7e2d elementor-widget elementor-widget-html\" data-id=\"4de7e2d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span id=\"bgn\"><\/span>\n<a href=\"https:\/\/inci.neuro.unistra.fr\/\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/02\/home.png\"><\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/#equipes\">Les \u00e9quipes<\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=2110\">Physiologie des r\u00e9seaux neuronaux<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-527af03 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"527af03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-35a0648\" data-id=\"35a0648\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-826d293 elementor-widget elementor-widget-heading\" data-id=\"826d293\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-e196b8c elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e196b8c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-03253c2\" data-id=\"03253c2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c26bf5f elementor-widget elementor-widget-text-editor\" data-id=\"c26bf5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8898\" aria-describedby=\"caption-attachment-8898\" style=\"width: 128px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"wp-image-8898\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Matilde.Cordero-214x300-1.jpg\" alt=\"\" width=\"128\" height=\"180\" \/><figcaption id=\"caption-attachment-8898\" class=\"wp-caption-text\"><span class=\"legende\">Matilde Cordero-Erausquin<\/span> (DR2, HDR)<\/figcaption><\/figure><p>Alors qu\u2019il est g\u00e9n\u00e9ralement admis que la fonction principale du tractus corticospinal <em>(CST)<\/em> est de transmettre des commandes motrices aux motoneurones bulbaires ou spinaux, nous avons r\u00e9cemment d\u00e9montr\u00e9 qu\u2019au niveau lombaire, il module principalement les entr\u00e9es sensorielles <em>(Moreno-Lopez et al, 2021)<\/em>.<\/p><p>Cette modulation permet le contr\u00f4le s\u00e9lectif du feedback sensoriel utilis\u00e9 pour assurer un mouvement bien coordonn\u00e9 et pr\u00e9cis.<\/p><p>De plus, nous avons montr\u00e9 que la commande motrice est principalement relay\u00e9e par d\u2019autres noyaux supraspinaux ou \u00e0 un autre niveau de la moelle \u00e9pini\u00e8re.<\/p><p>Notre projet vise maintenant \u00e0 enregistrer et \u00e0 manipuler la voie cortico-lombaire in vivo chez des souris libres de leurs mouvements, afin d\u2019identifier ses propri\u00e9t\u00e9s d\u2019encodage et sa contribution exacte \u00e0 divers comportements locomoteurs.<\/p><p>Pour ce faire, nous combinons des outils de pointe de tra\u00e7age de circuits sp\u00e9cifiques \u00e0 un type de cellule et d\u2019interf\u00e9rence avec l\u2019activit\u00e9, l\u2019\u00e9lectrophysiologie in vivo et l\u2019examen moteur chez la souris. Nous explorons \u00e9galement les collat\u00e9rales du CST, \u00e0 la fois au niveau supraspinal et spinal, afin d\u2019\u00e9lucider les voies indirectes v\u00e9hiculant l\u2019information corticospinale.<\/p><p>Le CST est touch\u00e9 d\u00e8s les premiers stades de la scl\u00e9rose lat\u00e9rale amyotrophique <em>(SLA)<\/em>, et la d\u00e9g\u00e9n\u00e9rescence du CST pourrait \u00eatre en partie responsable de la d\u00e9g\u00e9n\u00e9rescence ult\u00e9rieure des motoneurones bulbaires et spinaux.<\/p><p>Nous \u00e9tendons donc notre analyse du r\u00f4le du CST au contexte pathologique de la SLA, afin d\u2019\u00e9tudier la contribution du CST et du tractus cortico-r\u00e9ticulo-spinal \u00e0 la physiopathologie de cette maladie.<\/p><p>Ceci est fait dans le cadre de collaborations avec le Dr. Rouaux <em>(INSERM, Strasbourg)<\/em> et le Dr. Bouvier <em>(CNRS, Paris-Saclay)<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c767692 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c767692\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8d64797\" data-id=\"8d64797\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-53b66e4 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"53b66e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-bbb0303 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"bbb0303\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fbf138e\" data-id=\"fbf138e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-161e642 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"161e642\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>M<\/b>embres<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6a8df9c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6a8df9c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c48c2e0\" data-id=\"c48c2e0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f1d4a42 elementor-widget elementor-widget-text-editor\" data-id=\"f1d4a42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8949\" aria-describedby=\"caption-attachment-8949\" style=\"width: 143px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8949\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Gilles.Delbecq-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><figcaption id=\"caption-attachment-8949\" class=\"wp-caption-text\"><span class=\"legende\">Gilles Delbecq<\/span><br \/>(doctorant)<\/figcaption><\/figure><p>Mon projet de th\u00e8se porte sur l&rsquo;\u00e9tude du r\u00f4le des neurones corticospinaux dans l&rsquo;int\u00e9gration sensorimotrice au niveau de la moelle \u00e9pini\u00e8re lombaire. En couplant des techniques d&rsquo;optog\u00e9n\u00e9tique, d&rsquo;enregistrements extracellulaires dans le cortex et de motion capture, nous cherchons \u00e0 d\u00e9crypter comment cette population de neurones encode l&rsquo;information dans la r\u00e9alisation de mouvements des pattes post\u00e9rieures chez la souris, dans des conditions physiologiques, ainsi que dans le cadre pathologique de la scl\u00e9rose lat\u00e9rale amyotrophique.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1aa2fbe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1aa2fbe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f548a2f\" data-id=\"f548a2f\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e4cbb65 elementor-widget elementor-widget-text-editor\" data-id=\"e4cbb65\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8956\" aria-describedby=\"caption-attachment-8956\" style=\"width: 143px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8956\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Lea.Favier-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><figcaption id=\"caption-attachment-8956\" class=\"wp-caption-text\"><span class=\"legende\">L\u00e9a Favier<\/span><br \/>(doctorante)<\/figcaption><\/figure><p>Le but de mon \u00e9tude est d&rsquo;\u00e9tudier le r\u00f4le des voies corticospinale et cortico-reticulo-spinale dans la fonction sensorimotrice, chez la souris, dans un contexte physiologique, ainsi que dans le contexte pathologique de la scl\u00e9rose lat\u00e9rale amyotrophique. Pour ce faire, nous utiliserons un ensemble de techniques d&rsquo;enregistrements \u00e9lectrophysiologiques coupl\u00e9s \u00e0 des stimulations optog\u00e9n\u00e9tiques, et un syst\u00e8me d&rsquo;enregistrement du comportement moteur.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f00eed3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f00eed3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9006414\" data-id=\"9006414\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-052466c elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"052466c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-ad3c10a elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"ad3c10a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-11c4ab2\" data-id=\"11c4ab2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2ac306e elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"2ac306e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-0496a3e elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0496a3e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b8dea5a\" data-id=\"b8dea5a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ca574d1 elementor-widget elementor-widget-text-editor\" data-id=\"ca574d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Caroline Rouaux <em>(<a href=\"https:\/\/crbs.unistra.fr\/\" target=\"_blank\" rel=\"noopener\">CRBS<\/a>, INSERM, Strasbourg)<\/em><\/li><li>Jean Bouvier<em> (NeuroPsi, CNRS, Paris-Saclay)<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6db1183 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6db1183\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cd2beb4\" data-id=\"cd2beb4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7c31ffc elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"7c31ffc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-f2b039c elementor-section-content-bottom elementor-section-height-min-height elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle elementor-invisible\" data-id=\"f2b039c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-953cd7a\" data-id=\"953cd7a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c5580c3 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"c5580c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>P<\/b>ublications choisies<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-4436ffe elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4436ffe\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8f88552\" data-id=\"8f88552\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5629a2e elementor-widget elementor-widget-text-editor\" data-id=\"5629a2e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><a href=\"https:\/\/elifesciences.org\/articles\/65304\" target=\"_blank\" rel=\"noopener noreferrer\">The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord.<\/a> Moreno-Lopez Y, Bichara C, Delbecq G, Isope P, Cordero-Erausquin M. <strong><em>eLife<\/em><\/strong>, 2021 Sep 9;10:e65304.<\/p><p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0969996121001121?via%3Dihub\" target=\"_blank\" rel=\"noopener noreferrer\">Enhanced analgesic cholinergic tone in the spinal cord in a mouse model of neuropathic pain.<\/a> Dhanasobhon D, Medrano MC, Becker LJ, Moreno-Lopez Y, Kavraal S, Bichara C, Schlichter R, Inquimbert P, Yalcin I, Cordero-Erausquin M. <strong><em>Neurobiol Dis<\/em><\/strong>, 2021 Jul;155:105363.<\/p><p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ana.25833\" target=\"_blank\" rel=\"noopener noreferrer\">Absence of Subcerebral Projection Neurons Is Beneficial in a Mouse Model of Amyotrophic Lateral Sclerosis.<\/a> Burg T, Bichara C, Scekic-Zahirovic J, Fischer M, Stuart-Lopez G, Brunet A, Lefebvre F, Cordero-Erausquin M, Rouaux C. <strong><em>Ann Neurol<\/em><\/strong>, 2020 Oct;88(4):688-702.<\/p><p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26934510\" target=\"_blank\" rel=\"noopener noreferrer\">Loss of inhibitory tone on spinal cord dorsal horn spontaneously and nonspontaneously active neurons in a mouse model of neuropathic pain.<\/a> Medrano MC, Dhanasobhon D, Yalcin I, Schlichter R, Cordero-Erausquin M. <strong><em>Pain<\/em><\/strong>, 2016 Jul;157(7):1432-42.<\/p><p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/23447584\" target=\"_blank\" rel=\"noopener noreferrer\">A novel population of cholinergic neurons in the macaque spinal dorsal horn of potential clinical relevance for pain therapy.<\/a> Pawlowski SA, Gaillard S, Ghorayeb I, Ribeiro-da-Silva A, Schlichter R, Cordero-Erausquin M. <strong><em>J Neurosci<\/em><\/strong>, 2013 Feb 27;33(9):3727-37.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b33f615 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b33f615\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9fb8ec4\" data-id=\"9fb8ec4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7f412d2 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"7f412d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-a21590f elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"a21590f\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1ee3151\" data-id=\"1ee3151\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f409c33 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"f409c33\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>F<\/b>inancements<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-26fe852 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"26fe852\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-184cd5b\" data-id=\"184cd5b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8a5ace2 elementor-widget elementor-widget-image\" data-id=\"8a5ace2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/anr.fr\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/ANR-523x151-1-qdqnpbd9ca8trpbjq74dwtrr0juyqvnsqeo3wst2ww.jpg\" title=\"ANR-523&#215;151\" alt=\"ANR-523x151\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-0516faf\" data-id=\"0516faf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2c90047 elementor-widget elementor-widget-image\" data-id=\"2c90047\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/ARSLA-338x149-1-qdr63ty2eh6gxaz93knycn5s3iei2rsxtk2j3uhla8.png\" title=\"ARSLA-338&#215;149\" alt=\"ARSLA-338x149\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-0c5106f\" data-id=\"0c5106f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9d79e3a elementor-widget elementor-widget-image\" data-id=\"9d79e3a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/AFM-Telethon-450x95-1-qdr63ty2eh6gxaz93knycn5s3iei2rsxtk2j3uhla8.png\" title=\"AFM-Telethon-450&#215;95\" alt=\"AFM-Telethon-450x95\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-25 elementor-top-column elementor-element elementor-element-ab59173\" data-id=\"ab59173\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e14df02 elementor-widget elementor-widget-image\" data-id=\"e14df02\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/IDEX-298x300-1-qdr63wrkyzafzgc0ibmbrjm5yfpfz1idcn4jy9oef4.png\" title=\"IDEX-298&#215;300\" alt=\"IDEX-298x300\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-d18ba0a elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d18ba0a\" data-element_type=\"section\" 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Pr\u00e9sentation Alors qu\u2019il est g\u00e9n\u00e9ralement admis que la fonction principale du tractus corticospinal (CST) est de transmettre des commandes motrices aux motoneurones bulbaires ou spinaux, nous avons r\u00e9cemment d\u00e9montr\u00e9 qu\u2019au niveau lombaire, il module principalement les entr\u00e9es sensorielles (Moreno-Lopez et al, 2021). Cette modulation permet le contr\u00f4le s\u00e9lectif du feedback [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":2110,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4617","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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