{"id":4189,"date":"2023-03-01T15:04:10","date_gmt":"2023-03-01T14:04:10","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189"},"modified":"2024-03-14T15:20:42","modified_gmt":"2024-03-14T14:20:42","slug":"horloge-circadienne-sommeil-plasticite-homeostatique-dans-les-troubles-de-lhumeur","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189","title":{"rendered":"Horloge circadienne, sommeil &#038; plasticit\u00e9 hom\u00e9ostatique dans les troubles de l&rsquo;humeur"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"4189\" class=\"elementor elementor-4189\">\n\t\t\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-ea12194 elementor-section-full_width elementor-section-content-top elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"ea12194\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-ad6467d\" data-id=\"ad6467d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-63e59aa elementor-widget__width-initial elementor-widget elementor-widget-wp-widget-media_image\" data-id=\"63e59aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-media_image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1500\" height=\"500\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1.jpg\" class=\"image wp-image-20877  attachment-full size-full\" alt=\"\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1.jpg 1500w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1-300x100.jpg 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1-1024x341.jpg 1024w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1-768x256.jpg 768w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8fc64bb\" data-id=\"8fc64bb\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7d5280b elementor-widget-mobile__width-inherit elementor-widget elementor-widget-wp-widget-text\" data-id=\"7d5280b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"textwidget\"><p><a href=\"#bgn\"><strong class=\"titre-horloge-circadienne-sommeil\"><b>Horloge circadienne, sommeil &amp; plasticit\u00e9 hom\u00e9ostatique dans les troubles de l&rsquo;humeur<\/b><\/strong><\/a><\/p>\n<p><em><strong>Tsvetan SERCHOV<\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-39dbe53 elementor-section-full_width elementor-section-content-top elementor-section-height-default elementor-section-height-default\" data-id=\"39dbe53\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5eddbb4\" data-id=\"5eddbb4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4bb27ed elementor-widget elementor-widget-image\" data-id=\"4bb27ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"70\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png\" class=\"attachment-full size-full wp-image-20857\" alt=\"\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1-300x21.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1-768x54.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e414455 elementor-section-height-min-height elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"e414455\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-22ea655\" data-id=\"22ea655\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d1952a4 elementor-widget elementor-widget-html\" data-id=\"d1952a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span id=\"bgn\"><\/span>\n<a href=\"https:\/\/inci.neuro.unistra.fr\/\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/02\/home.png\"><\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/#equipes\">Les \u00e9quipes<\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=20615\">Sommeil, horloge, lumi\u00e8re & neuropsychiatrie<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-c0eb2bb elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"c0eb2bb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a386fda\" data-id=\"a386fda\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-baf0407 elementor-widget elementor-widget-heading\" data-id=\"baf0407\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-3b9739d elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3b9739d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ca4fae3\" data-id=\"ca4fae3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7768169 elementor-widget elementor-widget-text-editor\" data-id=\"7768169\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es.<\/p><p>Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne.<\/p><p>Aussi, les perturbations du sommeil et du rythme circadien sont associ\u00e9es au d\u00e9veloppement de diverses maladies psychiatriques. Les chronoth\u00e9rapies, comprenant diverses strat\u00e9gies de modulation de l\u2019horloge biologique et du cycle veille-sommeil <em>(privation de sommeil et luminoth\u00e9rapie)<\/em>, sont des traitements alternatifs des troubles de l\u2019humeur et du sommeil. Nous avons r\u00e9cemment montr\u00e9 que les effets antid\u00e9presseurs rapides de la privation aigu\u00eb de sommeil d\u00e9pendent d\u2019une augmentation de la signalisation ad\u00e9nosinergique et glutamat\u00e9rgique.<\/p><p>Cependant, l\u2019implication de l\u2019horloge circadienne dans l\u2019action antid\u00e9pressive de diff\u00e9rentes chronoth\u00e9rapies et dans la pathophysiologie des troubles de l\u2019humeur n\u2019est pas encore bien comprise.<\/p><p>En utilisant une combinaison de m\u00e9thodes de biologie mol\u00e9culaire, d\u2019\u00e9lectrophysiologie in vivo et d\u2019analyses comportementales complexes, nos objectifs sont :<\/p><ol><li>\u00c9tudier le r\u00f4le de l\u2019horloge circadienne dans la physiopathologie et le traitement de la d\u00e9pression.<\/li><li>Caract\u00e9riser l\u2019interaction entre les m\u00e9canismes circadiens et d\u2019hom\u00e9ostasie du sommeil sur la signalisation glutamat\u00e9rgique dans la th\u00e9rapie antid\u00e9pressive rapide.<\/li><li>\u00c9tudier l\u2019impact de la signalisation ad\u00e9nosinergique m\u00e9diant les effets de la perte de sommeil sur l\u2019humeur.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-8803a55 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"8803a55\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6dcb29c\" data-id=\"6dcb29c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f9553f elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"8f9553f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>hercheurs<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-c0e76a8 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c0e76a8\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-4154163\" data-id=\"4154163\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c2599ed elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c2599ed\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-5276ff5\" data-id=\"5276ff5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a5da32b elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"a5da32b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Tsvetan.Serchov-90x110-1-qe2tsbqc4tkxvkx6knvkl93hufbh8s25gg5la870u8.jpg\" title=\"Tsvetan.Serchov-90&#215;110\" alt=\"Tsvetan.Serchov-90x110\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Tsvetan Serchov<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-45dafc4\" data-id=\"45dafc4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-99e8f34\" data-id=\"99e8f34\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-3009c61 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"3009c61\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-af7c85e\" data-id=\"af7c85e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d2bbc9e elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"d2bbc9e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>P<\/b>ost-Doctorants \/ Doctorants<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-17f6c81 elementor-section-content-top elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"17f6c81\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-937ee4d\" data-id=\"937ee4d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-46dd6ba elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"46dd6ba\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-46ac64d\" data-id=\"46ac64d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b7db801 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"b7db801\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Wilg.Gardner-90x110-1-qgnpwl1m7c15jm9bp5exfp0nq4wy7x3nz07curbnr4.jpg\" title=\"Wilg.Gardner-90&#215;110\" alt=\"Wilg.Gardner-90x110\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Wilf Gardner <br><i>(post-doctorant)<\/i><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-5c31325\" data-id=\"5c31325\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-72c0a68 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"72c0a68\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=10643&#038;lang=en\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Xinling.Wang-214x300-1-qi5nmh6x0qgi99281g7wybsoqox0rmd4par65f1qm8.jpg\" title=\"Xinling.Wang-214&#215;300\" alt=\"Xinling.Wang-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=10643&#038;lang=en\">Xinling Wang <br><i>(post-doctorante)<\/i><\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-f261a27\" data-id=\"f261a27\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0e11a31 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"0e11a31\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/David.Sarrazin-214x300-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/David.Sarrazin-214x300-1-qgd78ejujglxzgypcvyjrcyqevqcygvti0u1vxunls.jpg\" title=\"David.Sarrazin-214&#215;300\" alt=\"David.Sarrazin-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/David.Sarrazin-214x300-1.jpg\">David Sarrazin <br><i>(doctorant)<\/i><\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-45e4b14 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"45e4b14\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d4582df\" data-id=\"d4582df\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-347bd0b elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"347bd0b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-11ec2d6 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"11ec2d6\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-00c2f2f\" data-id=\"00c2f2f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3c970b7 elementor-widget elementor-widget-text-editor\" data-id=\"3c970b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Prof. Dr. Claus Normann <em>(Psychiatry, Uniklinik Freiburg)<\/em><\/li><li>Prof. Dr. Bernd Fakler<em> (Physiology, University Freiburg)<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-efb08c1 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"efb08c1\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4f3fe88\" data-id=\"4f3fe88\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5735bc4 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"5735bc4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>A<\/b>pproches m\u00e9thodologiques<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-8ca06f8 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"8ca06f8\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f1c27c5\" data-id=\"f1c27c5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a737840 elementor-widget elementor-widget-text-editor\" data-id=\"a737840\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Genetically modified mouse models<br \/>Quantitative PCR, SDS-PAGE, Western blotting, Immunohystochemistry<br \/>Classical behavioral tests and complex automatic behavioral modeling and analyses via IntelliCage<br \/>In Vivo Electrophysiology: LFP and EEG <em>(sleep)<\/em> recordings<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-c359f70 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"c359f70\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f8f23d1\" data-id=\"f8f23d1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b50a387 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"b50a387\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>F<\/b>inancements<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-aed19da elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"aed19da\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7e22e7b\" data-id=\"7e22e7b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fbf87f1 elementor-widget elementor-widget-text-editor\" data-id=\"fbf87f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Fondation pour la Recherche Medical (<a href=\"https:\/\/www.frm.org\/\" target=\"_blank\" rel=\"noopener\">FRM<\/a>)<br \/>University of Strasbourg Institute for Advanced Studies (<a href=\"https:\/\/www.usias.fr\/\" target=\"_blank\" rel=\"noopener\">USIAS<\/a>)<br \/>German Research Foundation (<a href=\"https:\/\/www.dfg.de\/en\/\" target=\"_blank\" rel=\"noopener\">DFG<\/a>)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-888a687 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"888a687\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bfac6d4\" data-id=\"bfac6d4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1763505 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"1763505\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-543b116\" data-id=\"543b116\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ae668e5 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"ae668e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.frm.org\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-frm-244x200-1-q37grwjg8cyaatrqowgslu4cculfmy2wkuqh1w0xz4.jpg\" title=\"logo-frm-244&#215;200\" alt=\"logo-frm-244x200\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-45b9b3d\" data-id=\"45b9b3d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cdfc879 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"cdfc879\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.usias.fr\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-usias-244x200-1-q37grzcysv259nnn8foobbeq507ja1e3l8oxhpwrgg.jpg\" title=\"logo-usias-244&#215;200\" alt=\"logo-usias-244x200\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-2edd9db\" data-id=\"2edd9db\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3acf09e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"3acf09e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.dfg.de\/en\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-dfg-244x200-1-q37grtpxnuufbzvu5d8wwctykozbzurpkgs0m254hs.jpg\" title=\"logo-dfg-244&#215;200\" alt=\"logo-dfg-244x200\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-a3bca33\" data-id=\"a3bca33\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-aae7fb5 elementor-widget elementor-widget-image\" data-id=\"aae7fb5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/neurostra.unistra.fr\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo_neurostra-228x105-1-qgn8ynjrhh2iikh62uae8kggpfi2xfjf8o0ogz4jr4.jpg\" title=\"logo_neurostra-228&#215;105\" alt=\"logo_neurostra-228x105\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-8fab14e\" data-id=\"8fab14e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-10221e1 elementor-widget elementor-widget-image\" data-id=\"10221e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Logo_AAP_Idex-735x116-1-qgn8ynjrhh2jjecdsn80nx8yq4fahq4zdcakkmgao0.png\" title=\"Logo_AAP_Idex-735&#215;116\" alt=\"Logo_AAP_Idex-735x116\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-180d673 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"180d673\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-12b5c26\" data-id=\"12b5c26\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-439f28f elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"439f28f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-a605908 elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a605908\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7244691\" data-id=\"7244691\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-9513a48 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9513a48\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5389396\" data-id=\"5389396\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75dec56 elementor-widget elementor-widget-text-editor\" data-id=\"75dec56\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong>N<\/strong>os Publications<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-6026458\" data-id=\"6026458\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ccea8e4 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"ccea8e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/scholar.google.com\/citations?user=jF5-u_UAAAAJ&#038;hl=en\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" width=\"166\" height=\"63\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/google-scholar-166x63-1.png\" class=\"attachment-full size-full wp-image-13679\" alt=\"\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7b1c21e elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7b1c21e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fd4d513\" data-id=\"fd4d513\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cae3d09 elementor-widget elementor-widget-image\" data-id=\"cae3d09\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scholar.google.com\/citations?user=jF5-u_UAAAAJ&#038;hl=en\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" width=\"166\" height=\"63\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/google-scholar-166x63-1.png\" class=\"attachment-full size-full wp-image-13679\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5d5610c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5d5610c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-63a680e\" data-id=\"63a680e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-12552a5 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"12552a5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-8bbbe85 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"8bbbe85\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ff35601\" data-id=\"ff35601\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-01bb9ae elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"01bb9ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>P<\/b>ublicatons choisies<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-60038f2 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"60038f2\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cc38472\" data-id=\"cc38472\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c75110d elementor-widget elementor-widget-text-editor\" data-id=\"c75110d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Van Calker D,<strong> Serchov T*<\/strong>. <em>(2021)<\/em> The \u00ab\u00a0Missing Heritability\u00a0\u00bb-Problem in Psychiatry: Is the interaction of Genetics, Epigenetics and Transposable Elements a potential solution? <strong>Neurosci Biobehav Rev<\/strong>. S0149-7634 (21) 00134-2. doi: 10.1016\/j.neubiorev. 2021.03.019<\/p><p>Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, <strong>Serchov T<\/strong>, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castr\u00e9n E. (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell. 184<em>(5)<\/em>:1299-1313.e19. doi: 10.1016\/j.<strong>cell<\/strong>.2021.01.034.<\/p><p>Sun L, Verkaik-Schakel RK, Biber K, Pl\u00f6sch T, <strong>Serchov T*<\/strong> <em>(2021)<\/em> Antidepressant treatment is associated with epigenetic alterations of Homer1 promoter in a mouse model of chronic depression <strong>J Affect Disord<\/strong>. 279:501-509, doi: 10.1016\/j.jad.2020.10.040.<\/p><p><strong>Serchov T*<\/strong>, Schwarz I, Theiss A, Sun L, Holz A, D\u00f6br\u00f6ssy MD, Schwarz MK, Normann C, Biber K, van Calker D.<em> (2019)<\/em> Enhanced adenosine A1 receptor and Homer1a expression in hippocampus modulates the resilience to stress-induced depression-like behavior. <strong>Neuropharmacology<\/strong>. 107834. doi: 10.1016\/j.neuropharm.2019.<\/p><p>Holz A, M\u00fclsch F, Schwarz MK, Hollmann M, D\u00f6br\u00f6ssy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, <strong>Serchov T*<\/strong>. <em>(2019)<\/em> Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. <strong>Neuron<\/strong>. pii: S0896-6273(19)30637-3. doi: 10.1016\/j.neuron.2019.07.011. <\/p><p>Van Calker D, Biber K, Domschke K, <strong>Serchov T*<\/strong>. <em>(2019)<\/em> The Role of Adenosine Receptors in Mood and Anxiety Disorders.<strong> J Neurochem<\/strong>. doi: 10.1111\/jnc.14841. <\/p><p><strong>Serchov T<\/strong>, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M, Jacobson KA, de Bartolomeis A, Normann C, Biber K, van Calker D.<em> (2015)<\/em> Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. <strong>Neuron<\/strong>. 87(3):549-62. doi: 10.1016\/j.neuron.2015.07.010.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2048c45 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2048c45\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b2a66c1\" data-id=\"b2a66c1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1027b94 elementor-widget elementor-widget-spacer\" data-id=\"1027b94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Les \u00e9quipes&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Sommeil, horloge, lumi\u00e8re &#038; neuropsychiatrie Pr\u00e9sentation Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es. Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne. Aussi, les perturbations du sommeil et du rythme circadien sont associ\u00e9es au [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":20615,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4189","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Horloge circadienne, sommeil &amp; plasticit\u00e9 hom\u00e9ostatique dans les troubles de l&#039;humeur - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es. Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4189\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Horloge circadienne, sommeil &amp; plasticit\u00e9 hom\u00e9ostatique dans les troubles de l&#039;humeur - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es. Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4189\" \/>\n<meta property=\"og:site_name\" content=\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-14T14:20:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@incicnrs\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189\",\"name\":\"Horloge circadienne, sommeil & plasticit\u00e9 hom\u00e9ostatique dans les troubles de l'humeur - Institut des Neurosciences Cellulaires et Int\u00e9gratives\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/fleche-bas-HCS-PHTH-1000x70-1.png\",\"datePublished\":\"2023-03-01T14:04:10+00:00\",\"dateModified\":\"2024-03-14T14:20:42+00:00\",\"description\":\"Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es. Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189#breadcrumb\"},\"inLanguage\":\"fr-FR\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189#primaryimage\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/fleche-bas-HCS-PHTH-1000x70-1.png\",\"contentUrl\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/fleche-bas-HCS-PHTH-1000x70-1.png\",\"width\":1000,\"height\":70},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4189#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\",\"item\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Sommeil, horloge, lumi\u00e8re et neuropsychiatrie\",\"item\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=20615\"},{\"@type\":\"ListItem\",\"position\":4,\"name\":\"Horloge circadienne, sommeil &#038; plasticit\u00e9 hom\u00e9ostatique dans les troubles de l&rsquo;humeur\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#website\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/\",\"name\":\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\",\"description\":\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\",\"publisher\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"fr-FR\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#organization\",\"name\":\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"fr-FR\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/logo-inci-blanc-200px.png\",\"contentUrl\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/wp-content\\\/uploads\\\/2025\\\/12\\\/logo-inci-blanc-200px.png\",\"width\":200,\"height\":225,\"caption\":\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\"},\"image\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/incicnrs\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Horloge circadienne, sommeil & plasticit\u00e9 hom\u00e9ostatique dans les troubles de l'humeur - Institut des Neurosciences Cellulaires et Int\u00e9gratives","description":"Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es. Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189","og_locale":"fr_FR","og_type":"article","og_title":"Horloge circadienne, sommeil & plasticit\u00e9 hom\u00e9ostatique dans les troubles de l'humeur - Institut des Neurosciences Cellulaires et Int\u00e9gratives","og_description":"Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es. Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne.","og_url":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189","og_site_name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","article_modified_time":"2024-03-14T14:20:42+00:00","og_image":[{"url":"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png","type":"","width":"","height":""}],"twitter_card":"summary_large_image","twitter_site":"@incicnrs","twitter_misc":{"Dur\u00e9e de lecture estim\u00e9e":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189","url":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189","name":"Horloge circadienne, sommeil & plasticit\u00e9 hom\u00e9ostatique dans les troubles de l'humeur - Institut des Neurosciences Cellulaires et Int\u00e9gratives","isPartOf":{"@id":"https:\/\/inci.neuro.unistra.fr\/#website"},"primaryImageOfPage":{"@id":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189#primaryimage"},"image":{"@id":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189#primaryimage"},"thumbnailUrl":"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png","datePublished":"2023-03-01T14:04:10+00:00","dateModified":"2024-03-14T14:20:42+00:00","description":"Les troubles de l\u2019humeur font partie des maladies mentales invalidantes les plus fr\u00e9quemment diagnostiqu\u00e9es. Malgr\u00e9 les nombreuses hypoth\u00e8ses physiopathologiques, l\u2019\u00e9lucidation de la base neurobiologique de la d\u00e9pression reste l\u2019un des principaux d\u00e9fis de la psychiatrie moderne.","breadcrumb":{"@id":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189#breadcrumb"},"inLanguage":"fr-FR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/inci.neuro.unistra.fr\/?page_id=4189"]}]},{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189#primaryimage","url":"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png","contentUrl":"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png","width":1000,"height":70},{"@type":"BreadcrumbList","@id":"https:\/\/inci.neuro.unistra.fr\/?page_id=4189#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/inci.neuro.unistra.fr\/"},{"@type":"ListItem","position":2,"name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","item":"https:\/\/inci.neuro.unistra.fr\/"},{"@type":"ListItem","position":3,"name":"Sommeil, horloge, lumi\u00e8re et neuropsychiatrie","item":"https:\/\/inci.neuro.unistra.fr\/?page_id=20615"},{"@type":"ListItem","position":4,"name":"Horloge circadienne, sommeil &#038; plasticit\u00e9 hom\u00e9ostatique dans les troubles de l&rsquo;humeur"}]},{"@type":"WebSite","@id":"https:\/\/inci.neuro.unistra.fr\/#website","url":"https:\/\/inci.neuro.unistra.fr\/","name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","description":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","publisher":{"@id":"https:\/\/inci.neuro.unistra.fr\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/inci.neuro.unistra.fr\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"fr-FR"},{"@type":"Organization","@id":"https:\/\/inci.neuro.unistra.fr\/#organization","name":"Institut des Neurosciences Cellulaires et Int\u00e9gratives","url":"https:\/\/inci.neuro.unistra.fr\/","logo":{"@type":"ImageObject","inLanguage":"fr-FR","@id":"https:\/\/inci.neuro.unistra.fr\/#\/schema\/logo\/image\/","url":"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2025\/12\/logo-inci-blanc-200px.png","contentUrl":"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2025\/12\/logo-inci-blanc-200px.png","width":200,"height":225,"caption":"Institut des Neurosciences Cellulaires et Int\u00e9gratives"},"image":{"@id":"https:\/\/inci.neuro.unistra.fr\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/incicnrs"]}]}},"_links":{"self":[{"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages\/4189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4189"}],"version-history":[{"count":306,"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages\/4189\/revisions"}],"predecessor-version":[{"id":20917,"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages\/4189\/revisions\/20917"}],"up":[{"embeddable":true,"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=\/wp\/v2\/pages\/20615"}],"wp:attachment":[{"href":"https:\/\/inci.neuro.unistra.fr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}