{"id":4179,"date":"2023-03-01T15:03:15","date_gmt":"2023-03-01T14:03:15","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4179"},"modified":"2024-01-29T13:29:35","modified_gmt":"2024-01-29T12:29:35","slug":"lumiere-vision-cerveau","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4179","title":{"rendered":"Lumi\u00e8re, vision & cerveau"},"content":{"rendered":"\t\t
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Lumi\u00e8re, vision & cerveau<\/b><\/strong><\/a><\/p>\n

Marie-Paule FELDER-SCHMITTBUHL, Frank PFRIEGER<\/em>
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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/a>L\u2019\u00e9quipe s\u2019int\u00e9resse aux m\u00e9canismes mol\u00e9culaires et cellulaires impliqu\u00e9s dans la r\u00e9gulation de la physiopathologie r\u00e9tinienne, et de ses connexions fonctionnelles avec le cerveau.<\/p>

Nous \u00e9tudions d\u2019une part comment les interactions cellulaires au sein de la r\u00e9tine contr\u00f4lent son d\u00e9veloppement, sa survie, sa fonction, son vieillissement et sa vuln\u00e9rabilit\u00e9 ; et d\u2019autre part l\u2019int\u00e9gration de ces processus afin de v\u00e9hiculer les informations \u00e0 l\u2019horloge centrale et \u00e0 diff\u00e9rentes r\u00e9gions c\u00e9r\u00e9brales contr\u00f4lant le comportement.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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P<\/b>rojets de l'\u00e9quipe<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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> Organisation fonctionnelle et r\u00e9ponse \u00e0 la lumi\u00e8re des horloges r\u00e9tiniennes<\/a><\/strong><\/p>

Marie-Paule Felder-Schmittbuhl<\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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> Maladies r\u00e9tiniennes, handicap visuel et physiopathologie des c\u00f4nes<\/strong><\/a><\/strong><\/p>

David Hicks
<\/strong><\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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> Effets non visuels de la lumi\u00e8re bleue sur la r\u00e9tine et le cerveau<\/strong><\/strong><\/p>

Virginie Laurent-Gyd\u00e9
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> Implication des horloges c\u00e9r\u00e9brales synchronis\u00e9es par la lumi\u00e8re dans la r\u00e9gulation circadienne des comportements motiv\u00e9s<\/a><\/strong><\/p>

Jorge Mendoza
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> M\u00e9tabolisme du chol\u00e9st\u00e9rol dans la physiopathologie r\u00e9tinienne<\/strong><\/strong><\/p>

Frank Pfrieger
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\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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C<\/b>hercheurs<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/a><\/figure>

Amandine Bery<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/figure>

Marie-Paule Felder-Schmittbuhl<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/a><\/figure>

David Hicks<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/figure>

Virginie Laurent-Gyd\u00e9<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Jorge Mendoza<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/figure>

Frank Pfrieger<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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I<\/b>ng\u00e9nieurs & Techniciens<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"anonyme-214x300\"<\/figure>

Am\u00e9lie Barthelemy<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"anonyme-214x300\"<\/figure>

Na\u00efma El Kholti<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"anonyme-214x300\"<\/a><\/figure>

Cristina Sandu<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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P<\/b>ost-Doctorant \/ Doctorants<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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No\u00ebmi Maes<\/span>
(doctorante)<\/figcaption><\/figure>

Gr\u00e2ce aux horloges de notre corps nous sommes capables de ressentir la faim sans m\u00eame regarder l\u2019heure \u00e0 l\u2019approche de midi ou bien sentir la fatigue s\u2019installer d\u00e8s la nuit tomb\u00e9e. Ces signaux sont en phase avec les variations journali\u00e8res externes, telles que l\u2019alternance jour\/nuit. Or, lorsque nos horloges internes ne sont plus en phase avec l\u2019environnement (jet-lag, travail post\u00e9…)<\/em>, le risque de d\u00e9velopper des troubles mentaux tels que la d\u00e9pression est augment\u00e9. Mon projet de th\u00e8se consiste \u00e0 comprendre le r\u00f4le d\u2019une horloge pr\u00e9sente dans l\u2019hab\u00e9nula lat\u00e9rale, une structure c\u00e9r\u00e9brale bien connue mais dont l\u2019impact circadien sur l\u2019humeur n\u2019est pas clair. Pour cela, j\u2019utilise un mod\u00e8le de souris pr\u00e9sentant des perturbations circadiennes et j\u2019\u00e9value leur bien-\u00eatre. Pour pallier \u00e0 leurs troubles circadiens, j\u2019impose des horaires fixes d\u2019alimentation pour permettre d\u2019aligner leur activit\u00e9 avec l\u2019environnement. Gr\u00e2ce \u00e0 des techniques de bioluminescence et d\u2019hybridation in situ<\/em>, j\u2019analyse ensuite les cons\u00e9quences sur l\u2019expression de g\u00e8nes et prot\u00e9ines dans l\u2019hab\u00e9nula lat\u00e9rale.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Axelle Dat\u00e9<\/span>
(doctorante)<\/figcaption><\/figure>

Mon projet de th\u00e8se vise \u00e0 d\u00e9terminer comment l\u2019exposition nocturne \u00e0 la lumi\u00e8re bleue pendant l\u2019adolescence, contribue au d\u00e9veloppement de troubles circadiens, affectifs et cognitifs \u00e0 l\u2019\u00e2ge adulte. Dans une perspective translationnelle, j\u2019utilise un mod\u00e8le de rongeur diurne ; ayant une niche temporelle ainsi qu\u2019une composition cellulaire r\u00e9tinienne similaire \u00e0 celle de l\u2019homme : Arvicanthis ansorgei. A l’aide d’une batterie de tests comportementaux, j\u2019analyse l\u2019impact de la lumi\u00e8re bleue sur le syst\u00e8me circadien, l’humeur et la cognition. Afin de caract\u00e9riser les effets de cette exposition nocturne \u00e0 la lumi\u00e8re artificielle sur la fonction visuelle, l\u2019\u00e9tat de la r\u00e9tine, et les r\u00e9gions c\u00e9r\u00e9brales cibles, j\u2019effectue des enregistrements de l\u2019\u00e9lectror\u00e9tinogramme et combine des techniques d\u2019immunohistochimie et de tra\u00e7age.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Cl\u00e9ment Marcyniuk<\/span>
(doctorant)<\/figcaption><\/figure>

Les photor\u00e9cepteurs sont des neurones photosensibles de la r\u00e9tine qui convertissent les signaux lumineux en signaux \u00e9lectriques interpr\u00e9tables par le cerveau. Mais ce processus leur est toxique et n\u00e9cessite leur renouvellement quotidien. Mon projet de th\u00e8se consiste \u00e0 \u00e9tudier le r\u00f4le de la dyn\u00e9ine 1, prot\u00e9ine de transport essentielle \u00e0 ce renouvellement, dans les photor\u00e9cepteurs chez l\u2019homme. Pour ce faire je g\u00e9n\u00e8re des r\u00e9tines in vitro (ou organo\u00efdes)<\/em> \u00e0 partir de cellules de sujets sains ou de patients porteurs de mutations de la dyn\u00e9ine 1 et pr\u00e9sentant des troubles de la vision. A l\u2019aide de techniques d\u2019immunomarquage, de microscopie \u00e9lectronique et d\u2019imagerie calcique, et en observant diff\u00e9rents stades de leur d\u00e9veloppement, j\u2019analyse les effets de ces mutations sur le d\u00e9veloppement de la r\u00e9tine et l\u2019int\u00e9grit\u00e9 fonctionnelle, structurelle et morphologique des photor\u00e9cepteurs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Hugo Michelon<\/span>
(doctorant)<\/figcaption><\/figure>

Je m\u2019int\u00e9resse aux effets de la lumi\u00e8re bleue, que l\u2019on retrouve dans les \u00e9crans, sur le comportement agressif. J\u2019expose des souris \u00e0 une lumi\u00e8re bleue en d\u00e9but et fin de journ\u00e9e ce qui repr\u00e9sente des moments d\u2019exposition inappropri\u00e9s. Ensuite, je regarde par diff\u00e9rents tests comportementaux quels sont les effets sur l\u2019agressivit\u00e9 et l\u2019anxi\u00e9t\u00e9 des souris. Je souhaite \u00e9galement caract\u00e9riser les populations neuronales activ\u00e9es par la lumi\u00e8re bleue en utilisant des g\u00e8nes rapporteurs ainsi que des techniques d\u2019hybridation in situ et d\u2019immunohistochimie.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\"Catherine-Estay-Ahumada-90x110\"<\/figure>

Catherine-Estay Ahumada
(Post-doctorante)<\/i><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\t\t\t\t\t<\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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N<\/strong>os Publications<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Nos publications<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"logo_neurex-300x157\"<\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

  ⇨  Les \u00e9quipes Pr\u00e9sentation L\u2019\u00e9quipe s\u2019int\u00e9resse aux m\u00e9canismes mol\u00e9culaires et cellulaires impliqu\u00e9s dans la r\u00e9gulation de la physiopathologie r\u00e9tinienne, et de ses connexions fonctionnelles avec le cerveau. Nous \u00e9tudions d\u2019une part comment les interactions cellulaires au sein de la r\u00e9tine contr\u00f4lent son d\u00e9veloppement, sa survie, sa fonction, son vieillissement et sa vuln\u00e9rabilit\u00e9 ; et d\u2019autre part […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":67,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4179","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nLumi\u00e8re, vision & cerveau - 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