{"id":4170,"date":"2023-03-01T15:02:12","date_gmt":"2023-03-01T14:02:12","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=4170"},"modified":"2026-03-17T13:54:30","modified_gmt":"2026-03-17T12:54:30","slug":"traffic-membranaire-intracellulaire-dans-les-systemes-nerveux-et-neuroendocrines","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=4170","title":{"rendered":"Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines"},"content":{"rendered":"\t\t
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T<\/b>rafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines<\/strong><\/a><\/p>\n

St\u00e9phane GASMAN & Nicolas VITAL<\/span>E<\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Le fonctionnement des syst\u00e8mes nerveux et neuroendocrines repose sur la s\u00e9cr\u00e9tion de mol\u00e9cules informatives, un processus r\u00e9gul\u00e9 par un intense trafic membranaire (exocytose, endocytose, transport v\u00e9siculaire)<\/em>. \"\"<\/a><\/p>

Le but de nos recherches est de d\u00e9crypter les m\u00e9canismes mol\u00e9culaires qui contr\u00f4lent ces diff\u00e9rentes \u00e9tapes de trafic et d\u2019en r\u00e9v\u00e9ler les alt\u00e9rations qui sont \u00e0 la base de pathologies importantes (retard mental, maladies neurod\u00e9g\u00e9n\u00e9ratives, cancers neuroendocrines, ob\u00e9sit\u00e9\u2026)<\/em>.<\/p>

En utilisant des neurones, des cellules neuroendocrines ou des cellules gliales, nous \u00e9tudions plus particuli\u00e8rement les m\u00e9canismes qui permettent \u00e0 diff\u00e9rents lipides et prot\u00e9ines de contr\u00f4ler l\u2019ensemble des \u00e9tapes de la vie des v\u00e9sicules, allant de la biog\u00e9n\u00e8se jusqu\u2019\u00e0 la fusion membranaire, en passant par leur transport au sein des cellules.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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P<\/b>rojets de l'\u00e9quipe<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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> Endocytose compensatrice et recyclage v\u00e9siculaire<\/a><\/strong><\/p>

St\u00e9phane ORY, St\u00e9phane GASMAN<\/a><\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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> Formation des sites d’exocytose<\/a><\/strong><\/p>

Sylvette CHASSEROT-GOLAZ<\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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> Sites de contact membranaire et exocytose r\u00e9gul\u00e9e<\/strong><\/a><\/p>

Sylvette CHASSEROT-GOLAZ, Nicolas VITALE<\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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> S\u00e9cr\u00e9tions et tumeurs neuroendocrines<\/a><\/strong><\/p>

St\u00e9phane GASMAN<\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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> Transport des hormones m\u00e9taboliques vers le cerveau<\/a><\/strong><\/p>

St\u00e9phane ORY<\/a>, St\u00e9phane GASMAN
<\/strong><\/p><\/blockquote>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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> Cuivre et amyline dans la maladie d’Alzheimer<\/a><\/strong><\/p>

Nicolas VITALE
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C<\/b>hercheurs<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"sylvette\"<\/figure>

Sylvette Chasserot-Golaz<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Stef\"<\/a><\/figure>

St\u00e9phane Gasman<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Olga\"<\/a><\/figure>

Olga Gubar<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Steph-0\"<\/a><\/figure>

St\u00e9phane Ory<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Emeline\"<\/a><\/figure>

Emeline Tanguy<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Petra\"<\/a><\/figure>

Petra T\u00f3th<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\"Nico\"<\/a><\/figure>

Nicolas Vitale<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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I<\/b>ng\u00e9nieurs & Techniciens<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"claudine-boissier-90x110\"<\/figure>

Claudine Boissier<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"AMH\"<\/a><\/figure>

Anne-Marie Haeberl\u00e9<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"anonyme-214x300\"<\/figure>

Sebahat Ozkan<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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D<\/b>octorants et Post-doctorants<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"
Emma Darracq-Mousli<\/span>
(doctorante)<\/figcaption><\/figure>

Les bases mol\u00e9culaires de la s\u00e9cr\u00e9tion hormonale et de la neurotransmission ont longtemps \u00e9t\u00e9 \u00e9tudi\u00e9es \u00e0 travers le prisme des machineries prot\u00e9iques responsables de la fusion et du recyclage des v\u00e9sicules. Pourtant, la contribution des lipides membranaires \u00e0 ces processus reste largement sous-estim\u00e9e. Les phospholipides de la membrane plasmique sont distribu\u00e9s de mani\u00e8re asym\u00e9trique entre les deux feuillets de la bicouche, conf\u00e9rant \u00e0 la membrane une polarit\u00e9 structurale et fonctionnelle fondamentale. Nos travaux ont montr\u00e9 qu\u2019une perte locale et transitoire de cette asym\u00e9trie n\u2019est pas une simple cons\u00e9quence, mais une condition n\u00e9cessaire \u00e0 la s\u00e9cr\u00e9tion hormonale dans les cellules neuroendocrines et \u00e0 la neurotransmission dans des synapses \u00e0 haute fr\u00e9quence. Nous avons identifi\u00e9 la Scramblase-1 (PLSCR1) comme un r\u00e9gulateur central de ce processus. En effet, cette prot\u00e9ine perturbe localement l\u2019asym\u00e9trie lipidique pr\u00e8s des sites de fusion v\u00e9siculaire et r\u00e9gule le recyclage des v\u00e9sicules par endocytose compensatrice.<\/p>

Mon projet vise \u00e0 d\u00e9crypter comment la PLSCR1 orchestre le couplage entre exocytose et endocytose, et \u00e0 \u00e9tablir comment les variations dynamiques de l\u2019asym\u00e9trie membranaire gouvernent le cycle exo-endocytose des v\u00e9sicules de s\u00e9cr\u00e9tion. Pour r\u00e9pondre \u00e0 ces questions, nous combinons des approches avanc\u00e9es de biologie cellulaire avec des techniques d\u2019imagerie \u00e0 haute r\u00e9solution sur des cultures primaires de neurones en grains du cervelet.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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David Schmitt<\/span>
(doctorant)<\/figcaption><\/figure>

Mon projet de th\u00e8se en lien avec la maladie d\u2019Alzheimer et le diab\u00e8te de type 2 se trouve \u00e0 l\u2019interface entre la chimie et la biologie, celui-ci est financ\u00e9 par le programme 80\u2019 de la MITI du CNRS. Ces deux maladies impliquent une production excessive de peptides en mesure de s\u2019auto-assembler sous forme de fibres associ\u00e9es \u00e0 une certaine toxicit\u00e9 cellulaire. Il s\u2019agit des peptides amylo\u00efde-beta dans le cas d\u2019Alzheimer et de l\u2019amyline pour le diab\u00e8te de type 2. En r\u00e9alisant des \u00e9tudes de cin\u00e9tique de co-assemblage sur la formation de co-agr\u00e9gats, j\u2019\u00e9tudie l\u2019impact que peuvent exercer entre eux ces deux peptides. Des \u00e9tudes structurales permettent par ailleurs d\u2019observer et comparer les fibres form\u00e9es. L\u2019impact de ces co-agr\u00e9gats sur des cultures organotypiques d\u2019hippocampe de souris est \u00e9valu\u00e9 afin d\u2019en \u00e9tudier la toxicit\u00e9 par des approches immunocytochimique ainsi qu\u2019en mesurant l\u2019activit\u00e9 de r\u00e9seaux neuronaux par MEA. Cette th\u00e8se visant \u00e0 d\u00e9terminer si l\u2019amyline permet d\u2019\u00e9tablir un lien entre ces deux pathologies est r\u00e9alis\u00e9e en co-direction entre le Laboratoire de Chimie de Coordination<\/a><\/em> \u00e0 Toulouse et l\u2019INCI \u00e0 Strasbourg.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Alexander Wolf<\/span>
(Post-doctorant)<\/figcaption><\/figure>

Le r\u00f4le des lipides, constituants majeurs des membranes cellulaires, dans la lib\u00e9ration des neurotransmetteurs et des hormones reste encore mal compris, notamment \u00e0 cause d\u2019un manque d\u2019outils performant. Mon travail se base sur l\u2019utilisation d\u2019outils optog\u00e9n\u00e9tiques et la \u00ab\u00a0chimie click\u00a0\u00bb, pour d\u2019une part diriger des enzymes du m\u00e9tabolisme lipidique dans un compartiment sp\u00e9cifique et d\u2019autre part, introduire dans les membranes des lipides \u00ab\u00a0cliquables\u00a0\u00bb permettant d\u2019y greffer divers groupements fonctionnels. En utilisant ces outils novateurs sur des cellules chromaffines bovines, combin\u00e9 avec des approches de microscopie avanc\u00e9es ou de l\u2019\u00e9lectrochimie, j’explore les r\u00f4les pl\u00e9\u00efotropiques des lipides dans la neuros\u00e9cr\u00e9tion avec une pr\u00e9cision spatiale et temporelle in\u00e9gal\u00e9e.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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\u00a0<\/p>

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Mathys Bellemain\u2011Saignard<\/span>
(Post-doctorant)<\/figcaption><\/figure>

Mon projet postoctoral financ\u00e9 par un contrat ANR vise \u00e0 mieux comprendre le r\u00f4le des sites de contact membranaires (MCS) dans la r\u00e9gulation de l\u2019exocytose qui est un processus cellulaire essentiel permettant la lib\u00e9ration d\u2019hormones, de prot\u00e9ines et de neurotransmetteurs. En effet, bien que les m\u00e9canismes centraux de fusion v\u00e9siculaire soient connus, les m\u00e9canismes fins qui emp\u00eachent une s\u00e9cr\u00e9tion al\u00e9atoire restent encore mal compris. J\u2019ai pour objectif d\u2019\u00e9tudier la formation et la dynamique de ces MCS, leur influence sur l\u2019hom\u00e9ostasie calcique pr\u00e8s des sites d\u2019exocytose, ainsi que leur r\u00f4le dans le transfert de lipides essentiels au bon d\u00e9roulement de la s\u00e9cr\u00e9tion. Pour cela, je vais combiner des investigations par imagerie avanc\u00e9e, de biochimie, et d\u2019\u00e9lectrochimie sur des mod\u00e8les cellulaires et murins. Ainsi, j\u2019ambitionne de produire des connaissances nouvelles sur la communication intracellulaire et sur la r\u00e9gulation d\u2019un processus biologique majeur, avec des retomb\u00e9es potentielles pour la compr\u00e9hension de certaines pathologies li\u00e9es \u00e0 des d\u00e9fauts d\u2019exocytose.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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N<\/strong>os Publications<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\"PubMed-400x164\"<\/a><\/figure>

cliquez ici<\/a><\/h3><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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  ⇨  Les \u00e9quipes Pr\u00e9sentation Le fonctionnement des syst\u00e8mes nerveux et neuroendocrines repose sur la s\u00e9cr\u00e9tion de mol\u00e9cules informatives, un processus r\u00e9gul\u00e9 par un intense trafic membranaire (exocytose, endocytose, transport v\u00e9siculaire). Le but de nos recherches est de d\u00e9crypter les m\u00e9canismes mol\u00e9culaires qui contr\u00f4lent ces diff\u00e9rentes \u00e9tapes de trafic et d\u2019en r\u00e9v\u00e9ler les alt\u00e9rations qui sont \u00e0 […]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":67,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-4170","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nTrafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"Le fonctionnement des syst\u00e8mes nerveux et neuroendocrines repose sur la s\u00e9cr\u00e9tion de mol\u00e9cules informatives, un processus r\u00e9gul\u00e9 par un intense trafic membranaire (exocytose, endocytose, transport v\u00e9siculaire).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4170\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"Le fonctionnement des syst\u00e8mes nerveux et neuroendocrines repose sur la s\u00e9cr\u00e9tion de mol\u00e9cules informatives, un processus r\u00e9gul\u00e9 par un intense trafic membranaire (exocytose, endocytose, transport v\u00e9siculaire).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inci.neuro.unistra.fr\/?page_id=4170\" \/>\n<meta property=\"og:site_name\" content=\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-17T12:54:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-TMISNN-1000x70-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@incicnrs\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"10 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4170\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=4170\",\"name\":\"Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines - 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