{"id":3705,"date":"2023-02-27T13:29:06","date_gmt":"2023-02-27T12:29:06","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=3705"},"modified":"2024-03-19T07:15:52","modified_gmt":"2024-03-19T06:15:52","slug":"etude-du-traitement-modulaire-de-linformation-dans-le-cortex-cerebelleux-en-conditions-normales-et-pathologiques","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=3705","title":{"rendered":"Traitement de l&rsquo;information dans le cortex c\u00e9r\u00e9belleux en conditions normales et pathologiques"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3705\" class=\"elementor elementor-3705\">\n\t\t\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-8b2bbbf elementor-section-full_width elementor-section-content-top elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"8b2bbbf\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e202722\" data-id=\"e202722\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-556f04f elementor-widget__width-initial elementor-widget elementor-widget-wp-widget-media_image\" data-id=\"556f04f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-media_image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1200x350-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"350\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1200x350-1.jpg\" class=\"image wp-image-15054  attachment-full size-full\" alt=\"\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1200x350-1.jpg 1200w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1200x350-1-300x88.jpg 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1200x350-1-1024x299.jpg 1024w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/physiologie-reseaux-neuronaux-1200x350-1-768x224.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-20f7520\" data-id=\"20f7520\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5184a75 elementor-widget-mobile__width-inherit elementor-widget elementor-widget-wp-widget-text\" data-id=\"5184a75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"textwidget\"><p><a href=\"#bgn\"><strong class=\"titre-physiologie-reseaux-neuronaux\">Traitement de l&rsquo;information dans le cortex c\u00e9r\u00e9belleux en conditions normales et pathologiques<\/strong><\/a><\/p>\n<p><strong><em>Philippe Isope, Fr\u00e9d\u00e9ric Doussau &amp; Bernard Poulain<\/em><br \/>\n<\/strong><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-109e7ee elementor-section-full_width elementor-section-content-top elementor-section-height-default elementor-section-height-default\" data-id=\"109e7ee\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c2a81e1\" data-id=\"c2a81e1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c3d7a09 elementor-widget elementor-widget-image\" data-id=\"c3d7a09\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"70\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1.png\" class=\"attachment-full size-full wp-image-5646\" alt=\"\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1.png 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1-300x21.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-PRN-1000x70-1-768x54.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-645ba47 elementor-section-height-min-height elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"645ba47\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a8e90f2\" data-id=\"a8e90f2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6f569b6 elementor-widget elementor-widget-html\" data-id=\"6f569b6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span id=\"bgn\"><\/span>\n<a href=\"https:\/\/inci.neuro.unistra.fr\/\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/02\/home.png\"><\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/#equipes\">Les \u00e9quipes<\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=2110\">Physiologie des r\u00e9seaux Neuronaux<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-bd2fa43 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"bd2fa43\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-53260de\" data-id=\"53260de\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b82775d elementor-widget elementor-widget-heading\" data-id=\"b82775d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-f1ac0a5 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f1ac0a5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4819837\" data-id=\"4819837\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bde35a6 elementor-widget elementor-widget-text-editor\" data-id=\"bde35a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8896\" aria-describedby=\"caption-attachment-8896\" style=\"width: 128px\" class=\"wp-caption alignleft\"><img decoding=\"async\" class=\"wp-image-8896\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Philippe.Isope-214x300-1.jpg\" alt=\"\" width=\"128\" height=\"180\" \/><figcaption id=\"caption-attachment-8896\" class=\"wp-caption-text\"><span class=\"legende\">Philippe Isope<\/span><\/figcaption><\/figure><p>Le cervelet joue un r\u00f4le central dans le contr\u00f4le et l&rsquo;apprentissage moteur des mouvements complexes ainsi que dans le timing pr\u00e9cis de toutes nos actions. Le cortex c\u00e9r\u00e9belleux est organis\u00e9 en modules biochimiquement et fonctionnellement identifiables. Notamment, les cellules de Purkinje appartiennent \u00e0 plusieurs classes qui forment un r\u00e9seau de bandes parasagittales appel\u00e9es Z\u00e9brines. Les \u00e9tudes fonctionnelles ont d\u00e9montr\u00e9 que certains modules pouvaient \u00eatre associ\u00e9s \u00e0 des t\u00e2ches sp\u00e9cifiques.Le but de nos travaux est (1) d&rsquo;identifier les modes op\u00e9ratoires qui r\u00e9gissent l&rsquo;organisation synaptique fonctionnelle des modules c\u00e9r\u00e9belleux, (2) de comprendre comment les microcircuits c\u00e9r\u00e9belleux influencent la coordination motrice et le s\u00e9quen\u00e7age des actions.<\/p><p>Nos questions sont les suivantes:<\/p><p>Comment les informations spatiales et temporelles sont-elles trait\u00e9es dans le cortex c\u00e9r\u00e9belleux ?<\/p><p>Comment le cervelet communique-t-il avec les autres r\u00e9gions du cerveau?<\/p><p>Pour r\u00e9pondre \u00e0 ces questions, nous combinons les approches \u00e9lectrophysiologiques in vitro et in vivo (animal \u00e9veill\u00e9s) \u00e0 des techniques d&rsquo;imagerie et l&rsquo;optog\u00e9n\u00e9tique sur des mod\u00e8les murins.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-def4140 elementor-section-content-top elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"def4140\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ff7ee2f\" data-id=\"ff7ee2f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-1dab4eb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1dab4eb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4d81eb4\" data-id=\"4d81eb4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-61a6785 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"61a6785\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Frederic.Doussau-214x300-1-qdgrhbhvvb6eyxysmmx5eqgh8001pegj4cpe6495hc.jpg\" title=\"Frederic.Doussau-214&#215;300\" alt=\"Frederic.Doussau-214x300\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Fr\u00e9d\u00e9ric Doussau (CRHC)<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ad1d089\" data-id=\"ad1d089\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fdc9be8 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"fdc9be8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Bernard.Poulain-214x300-1-qdgrhak1oh54nc05s4iiu8p0mm4ohpcss81wouajnk.jpg\" title=\"Bernard.Poulain-214&#215;300\" alt=\"Bernard.Poulain-214x300\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Bernard Poulain (DRCE, HDR)<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-87b5d2a elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"87b5d2a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-74412b8\" data-id=\"74412b8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-85f4c3b elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"85f4c3b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-e20813e elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"e20813e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-66f44c3\" data-id=\"66f44c3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-81494e8 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"81494e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>M<\/b>embres<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-51c013c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"51c013c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1c7bede\" data-id=\"1c7bede\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-006b774 elementor-widget elementor-widget-text-editor\" data-id=\"006b774\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8950\" aria-describedby=\"caption-attachment-8950\" style=\"width: 143px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Theo.Gagneux-214x300-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8950\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Theo.Gagneux-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><\/a><figcaption id=\"caption-attachment-8950\" class=\"wp-caption-text\"><span class=\"legende\">Th\u00e9o Gagneux<\/span><br \/>(doctorant)<\/figcaption><\/figure><p>J&rsquo;\u00e9tudie l&rsquo;organisation fonctionnelle dans le cortex c\u00e9r\u00e9belleux pour comprendre comment le cervelet contr\u00f4le la coordination et l\u2019adaptation motrice. En combinant les techniques de photostimulation et de patch-clamp sur tranches de cervelet, j\u2019\u00e9tablis des cartes synaptiques entre les cellules granulaires et les autres types cellulaires du cortex c\u00e9r\u00e9belleux dont les cellules de Purkinje et les interneurones de la couche mol\u00e9culaire. Je cartographie ces voies chez des souris na\u00efves ou entra\u00een\u00e9es afin de d\u00e9terminer si une alt\u00e9ration du comportement moteur induit une r\u00e9organisation des cartes synaptiques.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f77fa4c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f77fa4c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-29c4b7e\" data-id=\"29c4b7e\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d907445 elementor-widget elementor-widget-text-editor\" data-id=\"d907445\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8951\" aria-describedby=\"caption-attachment-8951\" style=\"width: 143px\" class=\"wp-caption alignright\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Pierre.Lecabec-214x300-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8951\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Pierre.Lecabec-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><\/a><figcaption id=\"caption-attachment-8951\" class=\"wp-caption-text\"><span class=\"legende\">Pierre Le Cabec<\/span> (doctorant)<\/figcaption><\/figure><p>La pr\u00e9diction temporelle est un aspect critique de la plupart des comportements. Cette recherche se concentre sur l&rsquo;\u00e9tude de la communication entre le cortex pr\u00e9frontal et le cervelet, deux structures cl\u00e9 pour la pr\u00e9diction temporelle. En utilisant des enregistrements \u00e9lectrophysiologiques multiunitaires lors de t\u00e2ches comportementales exigeant une pr\u00e9diction temporelle pr\u00e9cise, j\u2019\u00e9tudie les m\u00e9canismes r\u00e9gissant la pr\u00e9diction des<br \/>\u00e9v\u00e9nements.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4c6709e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4c6709e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c481ed7\" data-id=\"c481ed7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8ae7e94 elementor-widget elementor-widget-text-editor\" data-id=\"8ae7e94\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8953\" aria-describedby=\"caption-attachment-8953\" style=\"width: 143px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Jerome.Wandhammer-214x300-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8953\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Jerome.Wandhammer-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><\/a><figcaption id=\"caption-attachment-8953\" class=\"wp-caption-text\"><span class=\"legende\">J\u00e9r\u00f4me Wandhammer<\/span><br \/>(doctorant)<\/figcaption><\/figure><p>J\u2019\u00e9tudie l\u2019h\u00e9t\u00e9rog\u00e9n\u00e9it\u00e9 fonctionnelle des cellules granulaires <em>(CG)<\/em>. Pour cela, j\u2019exprime des opsines dans des clones de CG \u00e0 diff\u00e9rents moments du d\u00e9veloppement du cervelet, ou bien dans les aff\u00e9rences moussues. J\u2019utilise des techniques d\u2019\u00e9lectroporations in vivo ou des injections virales dans des souris g\u00e9n\u00e9tiquement modifi\u00e9es. Nous combinons l\u2019activation optog\u00e9n\u00e9tique structur\u00e9e sur tranches aigues de cervelet avec l\u2019enregistrement<br \/>en patch-clamp de cellules de Purkinje, afin de d\u00e9terminer les propri\u00e9t\u00e9s synaptiques des diff\u00e9rents groupes de CG.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1927715 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1927715\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ab38c3b\" data-id=\"ab38c3b\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-34f973b elementor-widget elementor-widget-text-editor\" data-id=\"34f973b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8955\" aria-describedby=\"caption-attachment-8955\" style=\"width: 143px\" class=\"wp-caption alignright\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/RajatChandra.Mishra-214x300-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8955\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/RajatChandra.Mishra-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><\/a><figcaption id=\"caption-attachment-8955\" class=\"wp-caption-text\"><span class=\"legende\">Rajet Chandra Mishra<\/span><br \/>(doctorant)<\/figcaption><\/figure><p>Je suis doctorant en neurosciences computationnelles sous la direction du Dr Philippe Isope et du Dr Arvind Kumar. J\u2019\u00e9tudie le r\u00f4le de la connectivit\u00e9 bidirectionnelle entre les noyaux gris centraux <em>(BG)<\/em> et le cervelet <em>(CB)<\/em> sur le contr\u00f4le moteur. Les dysfonctionnements dans ces r\u00e9gions ont \u00e9t\u00e9 associ\u00e9s \u00e0 des troubles moteurs comme la maladie de Parkinson et la dystonie, et il a \u00e9t\u00e9 constat\u00e9 que les sympt\u00f4mes peuvent \u00eatre att\u00e9nu\u00e9s en coupant les connexions BG-CB ou en stimulant le CB. Mon projet vise \u00e0 mod\u00e9liser la communication BG-CB \u00e0 l&rsquo;aide d&rsquo;outils issus de la th\u00e9orie des syst\u00e8mes dynamiques, de la physique statistique et de la th\u00e9orie des probabilit\u00e9s. Le projet est financ\u00e9 par l&rsquo;Institut d&rsquo;\u00e9tudes avanc\u00e9es de l&rsquo;Universit\u00e9 de Strasbourg<em> (USIAS)<\/em>. Pour plus de d\u00e9tails : Page Web USIAS du projet. <a href=\"https:\/\/www.usias.fr\/fellows\/fellows-2022\/arvind-kumar\/\" target=\"_blank\" rel=\"noopener\">https:\/\/www.usias.fr\/fellows\/fellows-2022\/arvind-kumar\/<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-85329e9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"85329e9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-df8f15b\" data-id=\"df8f15b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-c42a0b4 elementor-widget elementor-widget-text-editor\" data-id=\"c42a0b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_8948\" aria-describedby=\"caption-attachment-8948\" style=\"width: 143px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Christopher.Small-214x300-1.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-8948\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/10\/Christopher.Small-214x300-1.jpg\" alt=\"\" width=\"143\" height=\"200\" \/><\/a><figcaption id=\"caption-attachment-8948\" class=\"wp-caption-text\"><span class=\"legende\">Christophe Small<\/span> <br \/>(post-doctorant)<\/figcaption><\/figure><p>J&rsquo;ai effectu\u00e9 mon doctorat \u00e0 l&rsquo;Institut du cerveau du Queensland \u00e0 Brisbane, en Australie. Mon projet porte sur la maturation du cervelet, une partie du cerveau qui contr\u00f4le une multitude de t\u00e2ches motrices et non motrices. J&rsquo;\u00e9tudie notamment les propri\u00e9t\u00e9s fonctionnelles des cellules granulaires qui int\u00e8grent les informations sensorimotrices des fibres moussues. Mon projet s&rsquo;appuie sur la microscopie \u00e0 deux photons, l&rsquo;\u00e9lectrophysiologie et l&rsquo;imagerie confocale sur des tranches de cervelet de souris pour d\u00e9terminer comment les cellules granulaires \u00e9tablissent leurs connexions au cours des premiers stades du d\u00e9veloppement. Le projet explore notamment les facteurs qui d\u00e9finissent les propri\u00e9t\u00e9s fonctionnelles des cellules granulaires.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-33c6ff9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"33c6ff9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-46a2beb\" data-id=\"46a2beb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cad16c1 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"cad16c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-708b1d0 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"708b1d0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1dd23b0\" data-id=\"1dd23b0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2906b3c elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"2906b3c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-52c412e elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"52c412e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-47c4257\" data-id=\"47c4257\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5ffbaae elementor-widget elementor-widget-text-editor\" data-id=\"5ffbaae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Fekrije Selimi, Coll\u00e8ge de France, Paris<\/li><li>Daniela Popa et Cl\u00e9ment L\u00e9na, IBENS, Paris<\/li><li>Cathie Ventalon, IBENS, Paris<\/li><li>David Digregorio, Pasteur, Paris<\/li><li>Jean Livet, Institut de la Vision, Paris<\/li><li>Emmanuel Beaurepaire, Ecole Polytechnique, Paris-Saclay<\/li><li>Arvind Kumar, KTH, Su\u00e8de<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-eece245 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"eece245\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6cef183\" data-id=\"6cef183\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-57510c0 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"57510c0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bda2a41 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bda2a41\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c2b04a\" data-id=\"7c2b04a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-805bff1 elementor-position-left elementor-vertical-align-middle elementor-widget elementor-widget-image-box\" data-id=\"805bff1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/equipe2-figure1-280x286-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/equipe2-figure1-280x286-1-qf57rzbtujddphhni5leedpryll9dw6w0o0u8b181k.jpg\" title=\"equipe2-figure1-280&#215;286\" alt=\"equipe2-figure1-280x286\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><p class=\"elementor-image-box-description\">Tranche de cervelet de souris Glyt2 (en vert, cellules de Golgi Glyt2 positives ; en bleu, cellules de Golgi neurogranines) marqu\u00e9e pour la z\u00e9brine II (en rouge; Cellules de Purkinje marqu\u00e9es, anticorps donn\u00e9 par R Hawkes, Calgary) illustrant les modules c\u00e9r\u00e9belleux.<\/p><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1011d61 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1011d61\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0a45e69\" data-id=\"0a45e69\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ec047e5 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"ec047e5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-17b4da9 elementor-section-content-bottom elementor-section-height-min-height elementor-reverse-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle elementor-invisible\" data-id=\"17b4da9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t\t<div class=\"elementor-background-overlay\"><\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a9465c9\" data-id=\"a9465c9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6025217 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"6025217\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>P<\/b>ublications choisies<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-6590e1c elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6590e1c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9484b5a\" data-id=\"9484b5a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3167100 elementor-widget elementor-widget-text-editor\" data-id=\"3167100\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Binda F, Spaeth L, Kumar A, Isope P. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37495382\/\" target=\"_blank\" rel=\"noopener\">Excitation and Inhibition Delays within a Feedforward Inhibitory Pathway Modulate Cerebellar Purkinje Cell Output in Mice.<\/a> <strong>J Neurosci<\/strong>. 2023 Aug 16;43(33):5905-5917. doi: 10.1523\/JNEUROSCI.0091-23.2023. Epub 2023 Jul 26. PMID: 37495382; PMCID: PMC10436687.<\/p><p>Spaeth L, Bahuguna J, Gagneux T, Dorgans K, Sugihara I, Poulain B, Battaglia D, Isope P. <a href=\"https:\/\/www.nature.com\/articles\/s41467-022-27984-8\" target=\"_blank\" rel=\"noopener noreferrer\">Cerebellar connectivity maps embody individual adaptive behavior in mice.<\/a> <strong>Nat Commun<\/strong>. 2022 Jan 31;13(1):580. doi: 10.1038\/s41467-022-27984-8.<\/p><p>Gonz\u00e1lez-Calvo I, Iyer K, Carquin M, Khayachi A, Giuliani FA, Sigoillot SM, Vincent J, S\u00e9veno M, Veleanu M, Tahraoui S, Albert M, Vigy O, Bosso-Lef\u00e8vre C, Nadjar Y, Dumoulin A, Triller A, Bessereau JL, Rondi-Reig L, Isope P, Selimi F. <a href=\"https:\/\/elifesciences.org\/articles\/65712\" target=\"_blank\" rel=\"noopener noreferrer\">Sushi domain-containing protein 4 controls synaptic plasticity and motor learning.<\/a> <strong>eLife<\/strong>. 2021 Mar 4;10:e65712<\/p><p>Straub I, Witter L, Eshra A, Hoidis M, Byczkowicz N, Maas S, Delvendahl I, Dorgans K, Savier E, Bechmann I, Krueger M, Isope P, Hallermann S.<a href=\"https:\/\/elifesciences.org\/articles\/51771\" target=\"_blank\" rel=\"noopener noreferrer\"> Gradients in the mammalian cerebellar cortex enable Fourier-like transformation and improve storing capacity.<\/a> <strong>eLife<\/strong>. 2020 Feb 5;9:e51771. doi: 10.7554\/eLife.51771.<\/p><p>\u00d6zcan OO, Wang X, Binda F, Dorgans K, De Zeeuw CI, Gao Z, Aertsen A, Kumar A, Isope P.<a href=\"https:\/\/www.jneurosci.org\/content\/40\/1\/159.long\" target=\"_blank\" rel=\"noopener noreferrer\"> Differential Coding Strategies in Glutamatergic and GABAergic Neurons in the Medial Cerebellar Nucleus.<\/a> <strong>J Neurosci.<\/strong> 2020 Jan 2;40(1):159-170.<\/p><p>Dorgans K, Demais V, Bailly Y, Poulain B, Isope P, Doussau F. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31081751\" target=\"_blank\" rel=\"noopener noreferrer\">Short-term plasticity at cerebellar granule cell to molecular layer interneuron synapses expands information processing.<\/a> <strong>eLife<\/strong>. 2019 May 13;8. pii: e41586.<\/p><p>Grangeray-Vilmint A, Valera AM, Kumar A, Isope P. <a href=\"https:\/\/www.jneurosci.org\/content\/38\/22\/5153.long\" target=\"_blank\" rel=\"noopener noreferrer\">Short-Term Plasticity Combines with Excitation-Inhibition Balance to Expand Cerebellar Purkinje Cell Dynamic Range.<\/a> <strong>J Neurosci.<\/strong> 2018 May 30;38(22):5153-5167.<\/p><p>Doussau F, Schmidt H, Dorgans K, Valera AM, Poulain B, Isope P. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28990927\" target=\"_blank\" rel=\"noopener noreferrer\">Frequency-dependent mobilization of heterogeneous pools of synaptic vesicles shapes presynaptic plasticity.<\/a> <strong>eLife<\/strong> 2017 Oct 9;6. pii: e28935.<\/p><p>Valera AM, Binda F, Pawlowski SA, Dupont JL, Casella JF, Rothstein JD, Poulain B, Isope P. <a href=\"https:\/\/elifesciences.org\/articles\/09862\" target=\"_blank\" rel=\"noopener noreferrer\">Stereotyped spatial patterns of functional synaptic connectivity in the cerebellar cortex<\/a> <strong>eLife<\/strong>. 2016 Mar 16;5. pii: e09862.<\/p><p>Proville RD, Spolidoro M, Guyon N, Dugu\u00e9 GP, Selimi F, Isope P, Popa D, L\u00e9na C. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25064850\" target=\"_blank\" rel=\"noopener noreferrer\">Cerebellum involvement in cortical sensorimotor circuits for the control of voluntary movements.<\/a> <strong>Nat Neurosci.<\/strong> 2014 Sep;17(9):1233-9.<\/p><p>Chaumont J, Guyon N, Valera AM, Dugu\u00e9 GP, Popa D, Marcaggi P, Gautheron V, Reibel-Foisset S, Dieudonn\u00e9 S, Stephan A, Barrot M, Cassel JC, Dupont JL, Doussau F, Poulain B, Selimi F, L\u00e9na C, Isope P. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24046366\" target=\"_blank\" rel=\"noopener noreferrer\">Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge.<\/a> <strong>PNAS<\/strong>. 2013 Oct 1;110(40):16223-8.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f948052 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f948052\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-214ae41\" data-id=\"214ae41\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d8bb8e6 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"d8bb8e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-8919573 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"8919573\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-196947d\" data-id=\"196947d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f699f2c elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"f699f2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>F<\/b>inancements<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7ce494c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7ce494c\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-64a7779\" data-id=\"64a7779\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b46c56a elementor-widget elementor-widget-image\" data-id=\"b46c56a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/anr.fr\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/ANR-523x151-1-qdqnpbd9ca8trpbjq74dwtrr0juyqvnsqeo3wst2ww.jpg\" title=\"ANR-523&#215;151\" alt=\"ANR-523x151\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-de6a987\" data-id=\"de6a987\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a0d355b elementor-widget elementor-widget-image\" data-id=\"a0d355b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.frm.org\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/FRM-427x300-1-qdqndcv6e5vm5m5qf8rqw9kn0uhp2okyxwzainudq8.jpg\" title=\"FRM-427&#215;300\" alt=\"FRM-427x300\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-c93bf7a elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c93bf7a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wide\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-ba76987\" data-id=\"ba76987\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-94abe93 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"94abe93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.cnrs.fr\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-cnrs-90x90-1-qj3v6vvgsnn2tevosfanmdepxw40apnljb3p6fu2o0.gif\" title=\"logo-cnrs-90&#215;90-1\" alt=\"logo-cnrs-90x90-1\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-14f0558\" data-id=\"14f0558\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1d9c4a6 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"1d9c4a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.unistra.fr\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-unistra-300x108-1-q2j3awtn4c02lgt5sa19xzxmlovdwhruwidqzooqgw.webp\" title=\"logo-unistra-300&#215;108-1\" alt=\"logo-unistra-300x108-1\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-bc11120\" data-id=\"bc11120\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-edf59f5 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"edf59f5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.inserm.fr\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-inserm-300x124-1-q2j3axrhb61cx2rsmsfwihp372qr46vl8n18gyncao.webp\" title=\"logo-inserm-300&#215;124-1\" alt=\"logo-inserm-300x124-1\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-2fba854\" data-id=\"2fba854\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d43acb3 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"d43acb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/neurostra.unistra.fr\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo_neuropole-120x120-1-q26yiqr0wksximidr4v91uwtuwzk9hb57sr6lmdgqo.png\" title=\"logo_neuropole-120&#215;120\" alt=\"logo_neuropole-120x120\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-43a5bcf\" data-id=\"43a5bcf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0cf26d1 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"0cf26d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.neurex.org\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo_neurex-300x157-1-q26yiovciwq8s3496wbi7g7wldjzkwpg0ucn8h59fk.png\" title=\"logo_neurex-300&#215;157\" alt=\"logo_neurex-300x157\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Les \u00e9quipes&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Physiologie des r\u00e9seaux Neuronaux Pr\u00e9sentation Le cervelet joue un r\u00f4le central dans le contr\u00f4le et l&rsquo;apprentissage moteur des mouvements complexes ainsi que dans le timing pr\u00e9cis de toutes nos actions. Le cortex c\u00e9r\u00e9belleux est organis\u00e9 en modules biochimiquement et fonctionnellement identifiables. Notamment, les cellules de Purkinje appartiennent \u00e0 plusieurs classes qui forment un r\u00e9seau [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"parent":2110,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-3705","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - 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