{"id":20303,"date":"2024-02-16T07:52:43","date_gmt":"2024-02-16T06:52:43","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=20303"},"modified":"2024-03-19T07:33:13","modified_gmt":"2024-03-19T06:33:13","slug":"dd-3","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=20303&lang=en","title":{"rendered":"Effect of endocrine disruptors on rhythms in reproduction and metabolism"},"content":{"rendered":"\t\t
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Effect of endocrine disruptors on rhythms in reproduction and metabolism<\/b><\/strong><\/a><\/p>\n

Val\u00e9rie Simonneaux, Paul Klosen<\/em>
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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  The teams<\/a>  ⇨  Regulation and disruption of neuroendocrine rhythms<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Presentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Given the fundamental role played by T3 in the seasonal regulation of biological functions, and the increasing reports of neuroendocrine alterations upon exposure to endocrine disruptors we have raised the hypothesis that exposure of seasonal species to thyroid-type endocrine disruptors alters their perception of the seasons and the adaptation of their biological functions. We have data indicating that chronic exposure to various low doses of bisphenol A (BPA)<\/em> alter Siberian hamster reproductive and metabolic photoperiodic adapation, as well as expression of some hypothalamic genes (among Dio2\/3, POMC, NPY, Kp, RFRP3, SOM)<\/em> with major sex differences.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Additionnaly, we are testing thet hypothesis that perinatal (gestation and lactation)<\/em> exposure to BPA has effects on maternal behavior, offspring\u2019s metabolic and reproductive development, and offspring\u2019s response to change in photoperiod during adulthood. This project is supported by fundings from ANSES and Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Endocrinologie.
The effects of BPA and other endocrine disruptors will also be assessed on circadian rhythms of planarians (i.e. locomotor behaviors, melatonin synthesis and clock gene expression)<\/em>. In addition, regeneration and its rhythmicity will also be looked at since BPA has been shown to disrupt regeneration in planarians and since regeneration is also circadian time-dependent. Besides adding basic knowledge of the mechanisms involved, the use of planarian as an animal model is expected to lead to the development of large-scale screening for circadian endocrine disruptors and for counter-acting drug treatments.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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T<\/b>eam members<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Val\u00e9rie Simonneaux<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Paul.Klosen-90x110\"<\/figure>

Paul Klosen<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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S<\/b>elected publications<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Moralia MA, Quignon C, Simonneaux M, Simonneaux V. Environmental disruption of reproductive rhythms. Front Neuroendocrinol. 2022 Jul;66:100990. doi: 10.1016\/j.yfrne.2022.100990<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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  ⇨  The teams  ⇨  Regulation and disruption of neuroendocrine rhythms Presentation Given the fundamental role played by T3 in the seasonal regulation of biological functions, and the increasing reports of neuroendocrine alterations upon exposure to endocrine disruptors we have raised the hypothesis that exposure of seasonal species to thyroid-type endocrine disruptors alters their perception of the seasons and […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":20097,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-20303","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nEffect of endocrine disruptors on rhythms in reproduction and metabolism - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"Given the fundamental role played by T3 in the seasonal regulation of biological functions, and the increasing reports of neuroendocrine alterations upon exposure to endocrine disruptors we have raised the hypothesis that exposure of seasonal species to thyroid-type endocrine disruptors alters their perception of the seasons and the adaptation of their biological functions\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=20303&lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effect of endocrine disruptors on rhythms in reproduction and metabolism - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"Given the fundamental role played by T3 in the seasonal regulation of biological functions, and the increasing reports of neuroendocrine alterations upon exposure to endocrine disruptors we have raised the hypothesis that exposure of seasonal species to thyroid-type endocrine disruptors alters their perception of the seasons and the adaptation of their biological functions\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inci.neuro.unistra.fr\/?page_id=20303&lang=en\" \/>\n<meta property=\"og:site_name\" content=\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-19T06:33:13+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-HCM-1000x70-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@incicnrs\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=20303&lang=en\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=20303&lang=en\",\"name\":\"Effect of endocrine disruptors on rhythms in reproduction and metabolism - 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