{"id":20230,"date":"2024-02-16T07:12:15","date_gmt":"2024-02-16T06:12:15","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=20230"},"modified":"2024-03-19T07:35:18","modified_gmt":"2024-03-19T06:35:18","slug":"neuroendocrine-mechanisms-regulating-seasonal-functions","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=20230&lang=en","title":{"rendered":"Neuroendocrine mechanisms regulating seasonal functions"},"content":{"rendered":"\t\t
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Neuroendocrine mechanisms regulating seasonal functions<\/b><\/strong><\/a><\/p>\n

Val\u00e9rie Simonneaux, Paul Klosen, Aur\u00e9lia Ces, Vincent Joseph Poirel, Vebjorn Melum, Louise Sicot<\/em>
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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  The teams<\/a>  ⇨  Regulation and disruption of neuroendocrine rhythms<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Presentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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The seasonal change in the nocturnal secretion of the pineal hormone melatonin is decoded into a summer\/long photoperiod increase in TSH (thyroid stimulating hormone)<\/em> synthesis by the pars tuberalis of the hypophysis. TSH in turn increases the capacity of the tanycytes (radial glial cells located at the basal part of the 3rd ventricle)<\/em> to convert T4 into the bioactive T3 in the neighboring hypothalamus (Dardente & Simonneaux, Front NeuroEndo, 2022 for review)<\/em>.<\/p>

Our current objective is to test the hypothesis that tanycytes and specific hypothalamic neuronal populations are critical to adapt long term biological activities such as reproduction, metabolism, hibernation, and neurogliogenesis with the seasons.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Reproduction<\/strong>: The hypothalamic peptide (Arg)(Phe)<\/em> related peptide 3 (RFRP3)<\/em>, known the regulate GnRH neuron activity, is strongly inhibited in short days\/winter conditions in all seasonal mammals. We are testing the hypothesis of a pivotal role of RFRP3 neurons in the melatonin-driven adaptation of reproduction with the seasons in collaboration with Dr H. Dardente (INRA, Nouzilly; ANR GMO-Phen)<\/em>. In both Syrian hamster and sheep, we are developing the Crispr-Cas9 technology for unconventional to evaluate the effect of RFRP3 knock-out on seasonal reproduction, and we are comparing the photoperiodic change in the RFRP3 neuron transcriptome. <\/p>

Hibernation<\/strong>: Syrian hamsters kept in short photoperiod at low temperature is able to hibernate. We are elucidating the neuroendocrine pathways involved in the onset\/off set of hibernation cycles in collaboration with D. Hazlerigg and S. Wood from the Artic University of Tromso (Norway; INSB Diverity ion Biological Mechnisms fundings)<\/em>. Preliminary data show that TSH, infused icv via programmable refillable osmotic minipumps, prevent hypothermic bouts. Further, in specific hypothalamic areas, cells yet to be identified are activated at different stages of the hibernation cycle.<\/p>

Seasonal neurogliogenesis<\/strong>: Seasonal adaptation involves large changes in hypothalamic cell plasticity and gene expression. Transfert in short photoperiod is associated with increased hypothalamic neuro-gliogeneis. We are investigating the seasonal signals regulating this short photoperiod-induced cell proliferation, the fate of the proliferative cells, and the putative role of the short photoperiod-induced genesis of these new hypothalamic cells in seasonal functions. <\/p>

Seasonal maternal programming<\/strong>: Maternal melatonin is able to program offspring\u2019s development, as hamsters born from a maternal gestation under summer\/long photoperiod have a faster metabolic and reproductive development than hamsters born from a maternal gestation under winter\/short photoperiod. In collaboration with S. Wood and D. Hazlerigg from the Artic University of Tromso (Norway)<\/em>, we are investigating the role tanaycyte plasticity in this melatonin-driven seasonal maternal programming. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Val\u00e9rie Simonneaux<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Paul Klosen<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Aur\u00e9lia Ces<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Vincent-Joseph.Poirel-214x300\"<\/a><\/figure>

Vincent-Joseph Poirel<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"vebjorn-melum-90x110\"<\/figure>

Vebj\u00f8rn Melum<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Louise.SICOT\"<\/a><\/figure>

Louise Sicot<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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S<\/b>elected publications<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Melum VJ, S\u00e1enz de Miera C, Markussen FAF, C\u00e1zarez-M\u00e1rquez F, Jaeger C, Sandve SR, Simonneaux V, Hazlerigg DG, Wood SH. Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity. Curr Biol. 2024 :S0960-9822(23)01742-6. doi: 10.1016\/j.cub.2023.12.042<\/p>

Dardente H, Simonneaux V. GnRH and the photoperiodic control of seasonal reproduction: Delegating the task to kisspeptin and RFRP-3. J Neuroendocrinol. 2022 34(5):e13124. doi: 10.1111\/jne.13124<\/p>

S\u00e1enz de Miera C, Bothorel B, Jaeger C, Simonneaux V, Hazlerigg D. Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland. Proc Natl Acad Sci U S A. 2017 ;114(31):8408-8413. doi:10.1073\/pnas.1702943114<\/p>

Henningsen JB, Ancel C, Mikkelsen JD, Gauer F, Simonneaux V. Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters. Endocrinology. 2017 ;158(3):652-663. doi: 10.1210\/en.2016-1689<\/p>

S\u00e1enz de Miera C, Monecke S, Bartzen-Sprauer J, Laran-Chich MP, P\u00e9vet P, Hazlerigg DG, Simonneaux V. A circannual clock drives expression of genes central for seasonal reproduction. Curr Biol. 2014; 24(13):1500-6. doi: 10.1016\/j.cub.2014.05.024<\/p>

Klosen P, S\u00e9bert ME, Rasri K, Laran-Chich MP, Simonneaux V. TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin. FASEB J. 2013 ;27(7):2677-86. doi: 10.1096\/fj.13-229559<\/p>

Ancel C, Bentsen AH, S\u00e9bert ME, Tena-Sempere M, Mikkelsen JD, Simonneaux V. Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: the exception proves the rule. Endocrinology. 2012 Mar;153(3):1352-63. doi: 10.1210\/en.2011-1622<\/p>

Revel FG, Herwig A, Garidou ML, Dardente H, Menet JS, Masson-P\u00e9vet M, Simonneaux V, Saboureau M, P\u00e9vet P. The circadian clock stops ticking during deep hibernation in the European hamster. Proc Natl Acad Sci U S A. 2007 ;104(34):13816-20. doi: 10.1073\/pnas.0704699104<\/p>

Revel FG, Saboureau M, Masson-P\u00e9vet M, P\u00e9vet P, Mikkelsen JD, Simonneaux V. Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Curr Biol. 2006 ;16(17):1730-5. doi: 10.1016\/j.cub.2006.07.025<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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  ⇨  The teams  ⇨  Regulation and disruption of neuroendocrine rhythms Presentation The seasonal change in the nocturnal secretion of the pineal hormone melatonin is decoded into a summer\/long photoperiod increase in TSH (thyroid stimulating hormone) synthesis by the pars tuberalis of the hypophysis. TSH in turn increases the capacity of the tanycytes (radial glial cells located at the […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":20097,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-20230","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nNeuroendocrine mechanisms regulating seasonal functions - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"The seasonal change in the nocturnal secretion of the pineal hormone melatonin is decoded into a summer\/long photoperiod increase in TSH (thyroid stimulating hormone) synthesis by the pars tuberalis of the hypophysis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=20230&lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neuroendocrine mechanisms regulating seasonal functions - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"The seasonal change in the nocturnal secretion of the pineal hormone melatonin is decoded into a summer\/long photoperiod increase in TSH (thyroid stimulating hormone) synthesis by the pars tuberalis of the hypophysis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inci.neuro.unistra.fr\/?page_id=20230&lang=en\" \/>\n<meta property=\"og:site_name\" content=\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-19T06:35:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-HCM-1000x70-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@incicnrs\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=20230&lang=en\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=20230&lang=en\",\"name\":\"Neuroendocrine mechanisms regulating seasonal functions - 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