{"id":19625,"date":"2024-02-02T07:42:52","date_gmt":"2024-02-02T06:42:52","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=19625"},"modified":"2024-03-19T07:29:36","modified_gmt":"2024-03-19T06:29:36","slug":"effet-des-perturbateurs-endocriniens-sur-les-rythmes-metaboliques-et-reproducteurs","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=19625","title":{"rendered":"Effet des perturbateurs endocriniens sur les rythmes de la reproduction et du m\u00e9tabolisme"},"content":{"rendered":"\t\t
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Effet des perturbateurs endocriniens sur les rythmes de la reproduction et du m\u00e9tabolisme<\/b><\/strong><\/a><\/p>\n

Val\u00e9rie Simonneaux, Paul Klosen<\/em>
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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>  ⇨  R\u00e9gulation et perturbation des rythmes neuroendocrines<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Compte tenu du r\u00f4le fondamental jou\u00e9 par la T3 dans la r\u00e9gulation saisonni\u00e8re des fonctions biologiques, et des rapports de plus en plus nombreux montrant des alt\u00e9rations neuroendocrines lors de l’exposition \u00e0 des perturbateurs endocriniens, nous avons \u00e9mis l’hypoth\u00e8se que l’exposition d’esp\u00e8ces saisonni\u00e8res \u00e0 des perturbateurs endocriniens de type thyro\u00efdien modifie leur perception des saisons et l’adaptation de leurs fonctions biologiques. Nous avons montr\u00e9 que l’exposition chronique \u00e0 diverses faibles doses de bisph\u00e9nol A (BPA)<\/em> modifie l’adaptation photop\u00e9riodique reproductive et m\u00e9tabolique du hamster sib\u00e9rien, ainsi que l’expression de certains g\u00e8nes hypothalamiques (parmi lesquels Dio2\/3, POMC, NPY, Kp, RFRP3, SOM)<\/em> avec des diff\u00e9rences majeures entre les sexes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t\"Equipe7-Fig7-1190x537\"\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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De plus, nous testons l’hypoth\u00e8se que l’exposition p\u00e9rinatale (gestation et lactation)<\/em> au BPA a des effets sur le comportement maternel, le d\u00e9veloppement m\u00e9tabolique et reproductif de la prog\u00e9niture, et la r\u00e9ponse de la prog\u00e9niture au changement de photop\u00e9riode \u00e0 l’\u00e2ge adulte. Ce projet est soutenu par des financements de l’ANSES et de la Soci\u00e9t\u00e9 Fran\u00e7aise d’Endocrinologie..
Les effets du BPA et d’autres perturbateurs endocriniens seront \u00e9galement \u00e9valu\u00e9s sur les rythmes circadiens des planaires (dont comportements locomoteurs, synth\u00e8se de m\u00e9latonine et expression des g\u00e8nes d’horloge)<\/em>. De plus, la r\u00e9g\u00e9n\u00e9ration et sa rythmicit\u00e9 seront \u00e9galement \u00e9tudi\u00e9es puisqu’il a \u00e9t\u00e9 d\u00e9montr\u00e9 que le BPA perturbe la r\u00e9g\u00e9n\u00e9ration chez les planaires et que la r\u00e9g\u00e9n\u00e9ration est \u00e9galement d\u00e9pendante du temps circadien. Outre l’acquisition de connaissances de base sur les m\u00e9canismes impliqu\u00e9s, l’utilisation du planaire comme mod\u00e8le animal devrait permettre de mettre au point un d\u00e9pistage \u00e0 grande \u00e9chelle des perturbateurs endocriniens circadiens et des traitements m\u00e9dicamenteux qui les neutralisent.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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M<\/b>embres de l'\u00e9quipe<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Valerie.Simonneaux-90x110\"<\/figure>

Val\u00e9rie Simonneaux<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Paul.Klosen-90x110\"<\/figure>

Paul Klosen<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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P<\/b>ublications choisies<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Moralia MA, Quignon C, Simonneaux M, Simonneaux V. Environmental disruption of reproductive rhythms. Front Neuroendocrinol. 2022 Jul;66:100990. doi: 10.1016\/j.yfrne.2022.100990<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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  ⇨  Les \u00e9quipes  ⇨  R\u00e9gulation et perturbation des rythmes neuroendocrines Pr\u00e9sentation Compte tenu du r\u00f4le fondamental jou\u00e9 par la T3 dans la r\u00e9gulation saisonni\u00e8re des fonctions biologiques, et des rapports de plus en plus nombreux montrant des alt\u00e9rations neuroendocrines lors de l’exposition \u00e0 des perturbateurs endocriniens, nous avons \u00e9mis l’hypoth\u00e8se que l’exposition d’esp\u00e8ces saisonni\u00e8res \u00e0 des perturbateurs endocriniens […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":19162,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-19625","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nEffet des perturbateurs endocriniens sur les rythmes de la reproduction et du m\u00e9tabolisme - 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