{"id":19422,"date":"2024-02-01T12:29:59","date_gmt":"2024-02-01T11:29:59","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=19422"},"modified":"2024-03-19T07:31:05","modified_gmt":"2024-03-19T06:31:05","slug":"mecanismes-neuroendocriniens-impliques-dans-la-regulation-des-fonctions-saisonnieres","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=19422","title":{"rendered":"M\u00e9canismes neuroendocriniens impliqu\u00e9s dans la r\u00e9gulation des fonctions saisonni\u00e8res"},"content":{"rendered":"\t\t
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M\u00e9canismes neuroendocriniens impliqu\u00e9s dans la r\u00e9gulation des fonctions saisonni\u00e8res<\/b><\/strong><\/a><\/p>\n

Val\u00e9rie Simonneaux, Paul Klosen, Aur\u00e9lia Ces, Vincent Joseph Poirel, Vebjorn Melum, Louise Sicot<\/em>
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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>  ⇨  R\u00e9gulation et perturbation des rythmes neuroendocrines<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Pr\u00e9sentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Le changement saisonnier de la s\u00e9cr\u00e9tion nocturne de l’hormone pin\u00e9ale, la m\u00e9latonine, est traduit en une augmentation en \u00e9t\u00e9\/longue photop\u00e9riode de la synth\u00e8se de TSH (thyroid stimulating hormone)<\/em> par la pars tuberalis de l’hypophyse. La TSH augmente \u00e0 son tour la capacit\u00e9 des tanycytes (cellules gliales radiales situ\u00e9es dans la partie basale du 3\u00e8me ventricule)<\/em> \u00e0 convertir la T4 en T3 bioactive dans l’hypothalamus voisin (Dardente & Simonneaux, Front NeuroEndo, 2022 pour revue)<\/em>.<\/p>

Notre objectif actuel est de tester l’hypoth\u00e8se selon laquelle les tanycytes et des populations neuronales hypothalamiques sp\u00e9cifiques sont essentiels pour adapter les activit\u00e9s biologiques \u00e0 long terme telles que la reproduction, le m\u00e9tabolisme, l’hibernation et la neurogliogen\u00e8se aux saisons.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Reproduction. <\/strong>Le peptide hypothalamique (Arg)(Phe)<\/em> related peptide 3 (RFRP3)<\/em>, connu pour r\u00e9guler l’activit\u00e9 des neurones GnRH, est fortement inhib\u00e9 dans les conditions de jours courts\/hiver chez tous les mammif\u00e8res saisonniers. En collaboration avec le Dr H. Dardente (INRA, Nouzilly ; ANR GMO-Phen)<\/em>, nous testons l’hypoth\u00e8se d’un r\u00f4le central des neurones RFRP3 dans l’adaptation saisonni\u00e8re de la reproduction. Chez le hamster syrien et le mouton, nous d\u00e9veloppons la technologie Crispr-Cas9 pour \u00e9valuer l’effet du knock-out de RFRP3 sur la reproduction saisonni\u00e8re, et nous comparons les changements photop\u00e9riodiques dans le transcriptome des neurones RFRP3.<\/p>

Hibernation<\/strong>. Les hamsters syriens maintenus dans une photop\u00e9riode courte \u00e0 basse temp\u00e9rature sont capables d’hiberner. Nous \u00e9lucidons les voies neuroendocriniennes impliqu\u00e9es dans le d\u00e9clenchement et l’arr\u00eat des cycles d’hibernation en collaboration avec D. Hazlerigg et S. Wood de l’Universit\u00e9 arctique de Tromso (Norv\u00e8ge ; financements INSB Diversity in Biological Mechanisms)<\/em>. Les donn\u00e9es pr\u00e9liminaires montrent que la TSH, perfus\u00e9e icv via des minipompes osmotiques programmables, emp\u00eache les \u00e9pisodes d’hypothermie. De plus, dans des zones hypothalamiques sp\u00e9cifiques, des cellules qui restent \u00e0 identifier sont activ\u00e9es \u00e0 diff\u00e9rents stades du cycle d’hibernation.<\/p>

Programmation maternelle saisonni\u00e8re<\/strong>. La m\u00e9latonine maternelle est capable de programmer le d\u00e9veloppement de la prog\u00e9niture, puisque des hamsters n\u00e9s d’une gestation maternelle sous photop\u00e9riode longue ont un d\u00e9veloppement m\u00e9tabolique et reproductif plus rapide que les hamsters n\u00e9s d’une gestation maternelle sous photop\u00e9riode courte. En collaboration avec S. Wood et d. Hazlerigg de l’Universit\u00e9 Arctique de Tromso (Norv\u00e8ge)<\/em>, nous \u00e9tudions le r\u00f4le de la plasticit\u00e9 des tanycytes dans cette programmation maternelle saisonni\u00e8re m\u00e9di\u00e9e par la m\u00e9latonine.<\/p>

Neurogliogen\u00e8se saisonni\u00e8re<\/strong>. L’adaptation saisonni\u00e8re implique d’importants changements dans la plasticit\u00e9 des cellules hypothalamiques et l’expression des g\u00e8nes. Le transfert en photop\u00e9riode courte est associ\u00e9 \u00e0 une augmentation de la neuro-gliogen\u00e8se hypothalamique. Nous \u00e9tudions les signaux saisonniers r\u00e9gulant cette prolif\u00e9ration cellulaire induite par photop\u00e9riode courte, le devenir des cellules prolif\u00e9ratives et le r\u00f4le putatif de ces nouvelles cellules hypothalamiques dans les fonctions saisonni\u00e8res.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\"Valerie.Simonneaux-90x110\"<\/figure>

Val\u00e9rie Simonneaux<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Paul.Klosen-90x110\"<\/figure>

Paul Klosen<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Aurelia.Ces-214x300\"<\/a><\/figure>

Aur\u00e9lia Ces<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Vincent-Joseph.Poirel-214x300\"<\/a><\/figure>

Vincent-Joseph Poirel<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"vebjorn-melum-90x110\"<\/figure>

Vebj\u00f8rn Melum<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Louise.SICOT\"<\/a><\/figure>

Louise Sicot<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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P<\/b>ublications choisies<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Melum VJ, S\u00e1enz de Miera C, Markussen FAF, C\u00e1zarez-M\u00e1rquez F, Jaeger C, Sandve SR, Simonneaux V, Hazlerigg DG, Wood SH. Hypothalamic tanycytes as mediators of maternally programmed seasonal plasticity. Curr Biol. 2024 :S0960-9822(23)01742-6. doi: 10.1016\/j.cub.2023.12.042<\/p>

Dardente H, Simonneaux V. GnRH and the photoperiodic control of seasonal reproduction: Delegating the task to kisspeptin and RFRP-3. J Neuroendocrinol. 2022 34(5):e13124. doi: 10.1111\/jne.13124<\/p>

S\u00e1enz de Miera C, Bothorel B, Jaeger C, Simonneaux V, Hazlerigg D. Maternal photoperiod programs hypothalamic thyroid status via the fetal pituitary gland. Proc Natl Acad Sci U S A. 2017 ;114(31):8408-8413. doi:10.1073\/pnas.1702943114<\/p>

Henningsen JB, Ancel C, Mikkelsen JD, Gauer F, Simonneaux V. Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters. Endocrinology. 2017 ;158(3):652-663. doi: 10.1210\/en.2016-1689<\/p>

S\u00e1enz de Miera C, Monecke S, Bartzen-Sprauer J, Laran-Chich MP, P\u00e9vet P, Hazlerigg DG, Simonneaux V. A circannual clock drives expression of genes central for seasonal reproduction. Curr Biol. 2014; 24(13):1500-6. doi: 10.1016\/j.cub.2014.05.024<\/p>

Klosen P, S\u00e9bert ME, Rasri K, Laran-Chich MP, Simonneaux V. TSH restores a summer phenotype in photoinhibited mammals via the RF-amides RFRP3 and kisspeptin. FASEB J. 2013 ;27(7):2677-86. doi: 10.1096\/fj.13-229559<\/p>

Ancel C, Bentsen AH, S\u00e9bert ME, Tena-Sempere M, Mikkelsen JD, Simonneaux V. Stimulatory effect of RFRP-3 on the gonadotrophic axis in the male Syrian hamster: the exception proves the rule. Endocrinology. 2012 Mar;153(3):1352-63. doi: 10.1210\/en.2011-1622<\/p>

Revel FG, Herwig A, Garidou ML, Dardente H, Menet JS, Masson-P\u00e9vet M, Simonneaux V, Saboureau M, P\u00e9vet P. The circadian clock stops ticking during deep hibernation in the European hamster. Proc Natl Acad Sci U S A. 2007 ;104(34):13816-20. doi: 10.1073\/pnas.0704699104<\/p>

Revel FG, Saboureau M, Masson-P\u00e9vet M, P\u00e9vet P, Mikkelsen JD, Simonneaux V. Kisspeptin mediates the photoperiodic control of reproduction in hamsters. Curr Biol. 2006 ;16(17):1730-5. doi: 10.1016\/j.cub.2006.07.025<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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  ⇨  Les \u00e9quipes  ⇨  R\u00e9gulation et perturbation des rythmes neuroendocrines Pr\u00e9sentation Le changement saisonnier de la s\u00e9cr\u00e9tion nocturne de l’hormone pin\u00e9ale, la m\u00e9latonine, est traduit en une augmentation en \u00e9t\u00e9\/longue photop\u00e9riode de la synth\u00e8se de TSH (thyroid stimulating hormone) par la pars tuberalis de l’hypophyse. La TSH augmente \u00e0 son tour la capacit\u00e9 des tanycytes (cellules gliales radiales […]<\/p>\n","protected":false},"author":10,"featured_media":0,"parent":19162,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-19422","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nM\u00e9canismes neuroendocriniens impliqu\u00e9s dans la r\u00e9gulation des fonctions saisonni\u00e8res - 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