{"id":16766,"date":"2023-12-15T15:29:13","date_gmt":"2023-12-15T14:29:13","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=16766"},"modified":"2024-03-19T07:11:22","modified_gmt":"2024-03-19T06:11:22","slug":"the-therapeutic-effect-of-platelet-rich-plasma-on-neuropathic-pain","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=16766&lang=en","title":{"rendered":"The therapeutic effect of platelet-rich plasma on neuropathic pain"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"16766\" class=\"elementor elementor-16766\">\n\t\t\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-820b65c elementor-section-full_width elementor-section-content-top elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"820b65c\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-e80961f\" data-id=\"e80961f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5656827 elementor-widget__width-initial elementor-widget elementor-widget-wp-widget-media_image\" data-id=\"5656827\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-media_image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/neuroanathomie-douleur-physiopathologies-1000x330-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1000\" height=\"330\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/neuroanathomie-douleur-physiopathologies-1000x330-1.jpg\" class=\"image wp-image-16725  attachment-full size-full\" alt=\"\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/neuroanathomie-douleur-physiopathologies-1000x330-1.jpg 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/neuroanathomie-douleur-physiopathologies-1000x330-1-300x99.jpg 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/neuroanathomie-douleur-physiopathologies-1000x330-1-768x253.jpg 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-f2676e9\" data-id=\"f2676e9\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-1506436 elementor-widget-mobile__width-inherit elementor-widget elementor-widget-wp-widget-text\" data-id=\"1506436\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"textwidget\"><p><a href=\"#bgn\"><strong class=\"titre-neuroanathomie-douleur-physiopathologies\"><strong>The therapeutic effect of platelet-rich plasma on neuropathic pain<\/strong><\/strong><\/a><\/p>\n<p><strong><em>M\u00e9lanie KREMER<\/em><br \/>\n<\/strong><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-db01541 elementor-section-full_width elementor-section-content-top elementor-section-height-default elementor-section-height-default\" data-id=\"db01541\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a4458f1\" data-id=\"a4458f1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-41e6867 elementor-widget elementor-widget-image\" data-id=\"41e6867\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"70\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-NDP-1000x70-1.png\" class=\"attachment-full size-full wp-image-5635\" alt=\"\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-NDP-1000x70-1.png 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-NDP-1000x70-1-300x21.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-NDP-1000x70-1-768x54.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-293d9c9 elementor-section-height-min-height elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"293d9c9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-82e19e3\" data-id=\"82e19e3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-454eefd elementor-widget elementor-widget-html\" data-id=\"454eefd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span id=\"bgn\"><\/span>\n<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=95&lang=en\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/02\/home.png\"><\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=95&lang=en#equipes\">Teams<\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=10611&lang=en\">Pain and psychopathology<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-c69d012 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"c69d012\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1ba0f6f\" data-id=\"1ba0f6f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac2274e elementor-widget elementor-widget-heading\" data-id=\"ac2274e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Presentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-c003a07 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c003a07\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-061f3fc\" data-id=\"061f3fc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-34618de elementor-widget elementor-widget-text-editor\" data-id=\"34618de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_16211\" aria-describedby=\"caption-attachment-16211\" style=\"width: 128px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Melanie.Kremer-214x300-1.jpg\"><img decoding=\"async\" class=\"wp-image-16211\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Melanie.Kremer-214x300-1.jpg\" alt=\"\" width=\"128\" height=\"180\" \/><\/a><figcaption id=\"caption-attachment-16211\" class=\"wp-caption-text\"><span class=\"legende\">M\u00e9lanie Kremer<\/span><\/figcaption><\/figure><p>Chronic pain not only causes physical suffering but also affects daily life, leading to symptoms such as irritability, aggression, withdrawal, and loss of autonomy. Additionally, it increases the risk of developing mood disorders. Therefore, managing chronic pain is a significant public health challenge. Neuropathic pain and post-surgical pain are two of the most common types of chronic pain encountered in the population. Unfortunately, these types of pain are difficult to alleviate and no satisfactory treatment is currently available.<\/p><p>In recent years, a new therapeutic tool has been developed in many medical fields: platelet-rich plasma <em>(PRP)<\/em> injection. PRP is an autologous platelet blood concentrate enriched with immune system messengers <em>(growth factors, cytokines, chemokines)<\/em>, adhesion molecules, and serotonin. It has been hypothesized that PRP could promote nerve regeneration after injury and reduce the neuro-immune response, thus potentially playing a protective and\/or analgesic role in neuropathic and persistent post-surgical pain.<\/p><p>In this context, our PRPain project aims to evaluate the therapeutic potential <em>(preventive and curative)<\/em> of PRP in a mouse model of neuropathic pain induced by sciatic nerve compression and to generalize this evaluation to another pain etiology, post-surgical pain, using a mouse model of paw incision. We then propose to validate the therapeutic importance of the platelet component of PRP. Finally, we will decipher the mechanism underlying the therapeutic action of PRP on neuropathic pain by analyzing gene expression changes in tissues associated with nerve injury and treatment (dorsal horn of the spinal cord, dorsal root ganglia, and sciatic nerve). The entire project will be performed in males and females.<\/p><p>Through the PRPain project, we aim to validate the use of PRP in the context of neuropathic and post-surgical pain and to advance our understanding of the molecular mechanisms associated with its therapeutic action. We hope that the results of the PRPain project will lead to the widespread use of PRP as an analgesic in a standardized fashion and open the door to new therapeutic targets.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-4dd5513 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"4dd5513\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f62aa59\" data-id=\"f62aa59\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-688039a elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"688039a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>T<\/b>eam members<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-d3dc032 elementor-section-content-top elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d3dc032\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2528815\" data-id=\"2528815\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e0b8885 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e0b8885\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-4bd373b\" data-id=\"4bd373b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b5f32ad elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"b5f32ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Melanie.Kremer-214x300-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Melanie.Kremer-214x300-1-qgd78fhoqan8b2xc7ed6buq709lq65zju5hjd7t9fk.jpg\" title=\"Melanie.Kremer-214&#215;300\" alt=\"Melanie.Kremer-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Melanie.Kremer-214x300-1.jpg\">M\u00e9lanie Kremer<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-933a662\" data-id=\"933a662\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-50c0081 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"50c0081\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Yohann.Bohren-214x300-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Yohann.Bohren-214x300-1-qgvy2hjhe9dllkgaz4zx1tzfodaepcpjmkiunort34.jpg\" title=\"Yohann.Bohren-214&#215;300\" alt=\"Yohann.Bohren-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Yohann.Bohren-214x300-1.jpg\">Yohann Bohren<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-ca05124\" data-id=\"ca05124\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-82d49d5 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"82d49d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Noemie.Willem-214x300-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Noemie.Willem-214x300-1-qgvy2ihbl3evx6extnejmbqw9r5rx1t9yp6c4yqeww.jpg\" title=\"Noemie.Willem-214&#215;300\" alt=\"Noemie.Willem-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/Noemie.Willem-214x300-1.jpg\">No\u00e9mie Willem<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-5c02850 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"5c02850\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b1b5d3d\" data-id=\"b1b5d3d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-66703d1 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"66703d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-1119435 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1119435\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e52916b\" data-id=\"e52916b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd4b7c1 elementor-widget elementor-widget-text-editor\" data-id=\"fd4b7c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Dr B\u00e9atrice HECHLER <em>(INSERM UMR-S1255, \u00ab\u00a0Etablissement Fran\u00e7ais du Sang &#8211; Grand Est\u00a0\u00bb, Strasbourg)<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-1e269ba elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"1e269ba\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-880a940\" data-id=\"880a940\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d8dcfb elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"4d8dcfb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>M<\/b>ethodological approaches<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-b4c5e4e elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b4c5e4e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ba9cb14\" data-id=\"ba9cb14\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3dffaa6 elementor-widget elementor-widget-text-editor\" data-id=\"3dffaa6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Murine pain models <em>(neuropathic, post-surgical&#8230;)<\/em><\/li><li>Behavioral tests: nociception <em>(von Frey filaments, Plantar, Dry ice&#8230;)<\/em><\/li><li>Behavioral pharmacology<\/li><li>Nerve tissue sampling<\/li><li>Collection and preparation of PRP<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-b69e81e elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"b69e81e\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-f1eae4a\" data-id=\"f1eae4a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8342798 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"8342798\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>F<\/b>unding<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-dcc995e elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dcc995e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-688d03d\" data-id=\"688d03d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-95b54a4 elementor-widget elementor-widget-text-editor\" data-id=\"95b54a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Agence Nationale pour la Recherche <em>(ANR)<\/em><\/li><li>Prix Sarter Analg\u00e9sia de la Soci\u00e9t\u00e9 Fran\u00e7aise d\u2019Etude pet de Traitement de la Douleur <em>(SFETD)<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-32da62a elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"32da62a\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wide\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-8903e01\" data-id=\"8903e01\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ddf93cc elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"ddf93cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.grandest.fr\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-grand-est-300x92-1-qlfdelx28rrak05dtm81ka5p5bb40m4yznnymesetc.jpg\" title=\"logo-grand-est-300&#215;92\" alt=\"logo-grand-est-300x92\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-d750f30\" data-id=\"d750f30\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b210ed1 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"b210ed1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/euridol.unistra.fr\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-euridol-372x80-1-qlfdek1dv3opws844lesfamryjkdl7xibecznuv75s.jpg\" title=\"logo-euridol-372&#215;80\" alt=\"logo-euridol-372x80\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Teams&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Pain and psychopathology Presentation Chronic pain not only causes physical suffering but also affects daily life, leading to symptoms such as irritability, aggression, withdrawal, and loss of autonomy. Additionally, it increases the risk of developing mood disorders. Therefore, managing chronic pain is a significant public health challenge. Neuropathic pain and post-surgical pain are two of [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":10611,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-16766","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>The therapeutic effect of platelet-rich plasma on neuropathic pain - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"Chronic pain not only causes physical suffering but also affects daily life, leading to symptoms such as irritability, aggression, withdrawal, and loss of autonomy. Additionally, it increases the risk of developing mood disorders. Therefore, managing chronic pain is a significant public health challenge. Neuropathic pain and post-surgical pain are two of the most common types of chronic pain encountered in the population\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=16766&lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The therapeutic effect of platelet-rich plasma on neuropathic pain - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"Chronic pain not only causes physical suffering but also affects daily life, leading to symptoms such as irritability, aggression, withdrawal, and loss of autonomy. Additionally, it increases the risk of developing mood disorders. Therefore, managing chronic pain is a significant public health challenge. Neuropathic pain and post-surgical pain are two of the most common types of chronic pain encountered in the population\" \/>\n<meta property=\"og:url\" content=\"https:\/\/inci.neuro.unistra.fr\/?page_id=16766&amp;lang=en\" \/>\n<meta property=\"og:site_name\" content=\"Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-19T06:11:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-NDP-1000x70-1.png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@incicnrs\" \/>\n<meta name=\"twitter:label1\" content=\"Dur\u00e9e de lecture estim\u00e9e\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=16766&lang=en\",\"url\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=16766&lang=en\",\"name\":\"The therapeutic effect of platelet-rich plasma on neuropathic pain - Institut des Neurosciences Cellulaires et Int\u00e9gratives\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=16766&lang=en#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/?page_id=16766&lang=en#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/inci.neuro.unistra.fr\\\/wp-content\\\/uploads\\\/2023\\\/03\\\/fleche-bas-NDP-1000x70-1.png\",\"datePublished\":\"2023-12-15T14:29:13+00:00\",\"dateModified\":\"2024-03-19T06:11:22+00:00\",\"description\":\"Chronic pain not only causes physical suffering but also affects daily life, leading to symptoms such as irritability, aggression, withdrawal, and loss of autonomy. 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