{"id":12662,"date":"2023-11-03T14:02:31","date_gmt":"2023-11-03T13:02:31","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=12662"},"modified":"2024-01-24T08:12:14","modified_gmt":"2024-01-24T07:12:14","slug":"functional-dynamics-of-opioid-receptors","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=12662&lang=en","title":{"rendered":"Functional dynamics of opioid receptors"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"12662\" class=\"elementor elementor-12662\">\n\t\t\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-0dc71e5 elementor-section-full_width elementor-section-content-top elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"0dc71e5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-831b41c\" data-id=\"831b41c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-52f8d2f elementor-widget__width-initial elementor-widget elementor-widget-wp-widget-media_image\" data-id=\"52f8d2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-media_image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Signalisation-nociceptive-moelle-epiniere-1200x300-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1200\" height=\"300\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Signalisation-nociceptive-moelle-epiniere-1200x300-1.jpg\" class=\"image wp-image-15077  attachment-full size-full\" alt=\"\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Signalisation-nociceptive-moelle-epiniere-1200x300-1.jpg 1200w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Signalisation-nociceptive-moelle-epiniere-1200x300-1-300x75.jpg 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Signalisation-nociceptive-moelle-epiniere-1200x300-1-1024x256.jpg 1024w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Signalisation-nociceptive-moelle-epiniere-1200x300-1-768x192.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" \/><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3560fc7\" data-id=\"3560fc7\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6e5842b elementor-widget-mobile__width-inherit elementor-widget elementor-widget-wp-widget-text\" data-id=\"6e5842b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"textwidget\"><p><a href=\"#bgn\"><strong class=\"titre-signalisation-nociceptive-moelle-epiniere\"><b>Functional dynamics of opioid receptors<\/b><\/strong><\/a><\/p>\n<p><em><strong>Dominique MASSOTTE<br \/>\n<\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3c42a80 elementor-section-full_width elementor-section-content-top elementor-section-height-default elementor-section-height-default\" data-id=\"3c42a80\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-946af04\" data-id=\"946af04\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-21888fa elementor-widget elementor-widget-image\" data-id=\"21888fa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"70\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-SNME-1000x70-1.png\" class=\"attachment-large size-large wp-image-5656\" alt=\"\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-SNME-1000x70-1.png 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-SNME-1000x70-1-300x21.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/03\/fleche-bas-SNME-1000x70-1-768x54.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6b7f7c1 elementor-section-height-min-height elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"6b7f7c1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ba6e2bb\" data-id=\"ba6e2bb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3a4b39d elementor-widget elementor-widget-html\" data-id=\"3a4b39d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span id=\"bgn\"><\/span>\n<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=95&lang=en\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/02\/home.png\"><\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=95&lang=en#equipes\">Teams<\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=10599&lang=en\">Opioid system, nociception and pain<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-bdeb210 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"bdeb210\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7fbae64\" data-id=\"7fbae64\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ec226d elementor-widget elementor-widget-heading\" data-id=\"3ec226d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Presentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-44190d7 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"44190d7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8a7674c\" data-id=\"8a7674c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-829dcfb elementor-widget elementor-widget-text-editor\" data-id=\"829dcfb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The opioid system is involved in a wide range of physiological outcomes. It modulates pain perception, affective behaviour and reward to natural stimuli such as food. It is involved in attention, learning and memory processes, controls autonomic functions and affects locomotor activity. It also plays a key role in the response of the organism to stress. In addition, this neuromodulatory system is the molecular target of opiates that have been used for centuries for their potent analgesic properties. However, tolerance develops during chronic opiate administration which represents a major limitation to their therapeutic use. Moreover, opiates possess euphoric properties promoting their abuse and\/or misuse thereby leading to drug addiction.<\/p><p><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/equipe3-figure4-300x188-1.jpg\"><img decoding=\"async\" class=\"alignright wp-image-13626\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/equipe3-figure4-300x188-1.jpg\" alt=\"\" width=\"240\" height=\"150\" \/><\/a>Our projects address the dynamics of opioid receptors in terms of neuroanatomical distribution, signalling and trafficking in their native environment both in physiological and pathological conditions. We aim at identifying molecular mechanisms by which these receptors modulate the activity of neurons and neural networks and, adapt to chronic opiates. An important axis focuses on the specific molecular and cellular mechanisms of heteromers resulting from the association of two different opioid receptors, mainly mu and delta, or involving an opioid receptor and a non-opioid one. Our goal is to determine the impact of such heteromers on the cellular physiology and behavioral responses and to evaluate their potential as novel therapeutic targets. We explore strategies targeting opioid heteromers in the context of chronic pain for which current opiate-based therapies remain poorly efficient and, which therefore represents a crucial unmet socioeconomical challenge. We also examine their therapeutic potential in the context of addictive behaviors towards opiate drugs and palatable food, a gateway to obesity that represents another major health issue. To these aims, we combine ex vivo and in vivo molecular, cellular and pharmacological approaches with behavioural tests and genetically modified mice.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-cf86016 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"cf86016\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4a57caf\" data-id=\"4a57caf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7567beb elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"7567beb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>T<\/b>eam members<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-38208c7 elementor-section-content-top elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"38208c7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-44495b1\" data-id=\"44495b1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-4452661 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"4452661\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-8eb3aa1\" data-id=\"8eb3aa1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-57f1727 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"57f1727\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Dominique.Massotte-214x300-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Dominique.Massotte-214x300-1-qg4i0w0vv19wtk2q55u7xkca0drum8a1td0kr87m68.jpg\" title=\"Dominique.Massotte-214&#215;300\" alt=\"Dominique.Massotte-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Dominique.Massotte-214x300-1.jpg\">Dominique Massotte<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-d03002c\" data-id=\"d03002c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-be5a0a7 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"be5a0a7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Ferdahous.Belhassine-214x300-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Ferdahous.Belhassine-214x300-1-qftp0581c5u3ciqy0j8iwm349xdk1wex0b8kd96osg.jpg\" title=\"Ferdahous.Belhassine-214&#215;300\" alt=\"Ferdahous.Belhassine-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/Ferdahous.Belhassine-214x300-1.jpg\">Ferbaous Belhassine<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-a4d9676 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"a4d9676\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-968df36\" data-id=\"968df36\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd08334 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"fd08334\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-07da05d elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"07da05d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3590dbf\" data-id=\"3590dbf\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-61e13d8 elementor-widget elementor-widget-text-editor\" data-id=\"61e13d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Katia Befort <em>(LNCA, Strasbourg, France)<\/em><\/li><li>Christiane Faeste <em>(Veterinary Institute, Oslo, Norway)<\/em><\/li><li>Sandra Lecat<em> (ESBS, Illkirch-Graffenstaden)<\/em><\/li><li>Susruta Majumdar <em>(University School of Medicine, St Louis, Missouri, USA)<\/em><\/li><li>Florence Noble <em>(University Paris Descartes, Paris, France)<\/em><\/li><li>Martine Schmitt <em>(Faculty of Pharmacy, University of Strasbourg, Illkirch Graffenstaden)<\/em><\/li><li>Stefan Schultz <em>(University of Jena, Germany)<\/em><\/li><li>Mariana Spetea <em>(University Innsbruck, Austria)<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c85b680 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c85b680\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c7f38a2\" data-id=\"c7f38a2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fc58b38 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"fc58b38\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-978bfa3 elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"978bfa3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-798e4ba\" data-id=\"798e4ba\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-00e5647 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"00e5647\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b00fde3\" data-id=\"b00fde3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f3a50f3 elementor-widget elementor-widget-text-editor\" data-id=\"f3a50f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong>O<\/strong>ur Publications<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-214a769\" data-id=\"214a769\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4baa8be elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"4baa8be\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1lKz2YIch-wku\/bibliography\/public\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/PubMed-400x164-1-qdnob2lkffnwktk0r03jcfugmdtq5llmhcses2ns3k.jpg\" title=\"PubMed-400&#215;164\" alt=\"PubMed-400x164\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5ec31e6 elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5ec31e6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-60c29a8\" data-id=\"60c29a8\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-44b1d1d elementor-widget elementor-widget-image\" data-id=\"44b1d1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1lKz2YIch-wku\/bibliography\/public\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/PubMed-400x164-1-qdnob2lkffnfe2zmb3lvdo593jxea9513mkmodz7y8.jpg\" title=\"PubMed-400&#215;164\" alt=\"PubMed-400x164\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-e12ad33 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e12ad33\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wide\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-8542db6\" data-id=\"8542db6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap 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elementor-col-20 elementor-top-column elementor-element elementor-element-9ee018c\" data-id=\"9ee018c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3a198fb elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"3a198fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.inserm.fr\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-inserm-300x124-1-q2j3axrhb61cx2rsmsfwihp372qr46vl8n18gyncao.webp\" title=\"logo-inserm-300&#215;124-1\" alt=\"logo-inserm-300x124-1\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-31a4946\" data-id=\"31a4946\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-11b868e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"11b868e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/neurostra.unistra.fr\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo_neuropole-120x120-1-q26yiqr0wksximidr4v91uwtuwzk9hb57sr6lmdgqo.png\" title=\"logo_neuropole-120&#215;120\" alt=\"logo_neuropole-120x120\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-top-column elementor-element elementor-element-97debae\" data-id=\"97debae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f442fe6 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"f442fe6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.neurex.org\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo_neurex-300x157-1-q26yiovciwq8s3496wbi7g7wldjzkwpg0ucn8h59fk.png\" title=\"logo_neurex-300&#215;157\" alt=\"logo_neurex-300x157\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Teams&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Opioid system, nociception and pain Presentation The opioid system is involved in a wide range of physiological outcomes. It modulates pain perception, affective behaviour and reward to natural stimuli such as food. It is involved in attention, learning and memory processes, controls autonomic functions and affects locomotor activity. It also plays a key role in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":10599,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-12662","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Functional dynamics of opioid receptors - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"The opioid system is involved in a wide range of physiological outcomes. It modulates pain perception, affective behaviour and reward to natural stimuli such as food. It is involved in attention, learning and memory processes, controls autonomic functions and affects locomotor activity\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=12662&lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Functional dynamics of opioid receptors - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"The opioid system is involved in a wide range of physiological outcomes. It modulates pain perception, affective behaviour and reward to natural stimuli such as food. 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