{"id":12538,"date":"2023-11-03T11:17:46","date_gmt":"2023-11-03T10:17:46","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=12538"},"modified":"2026-03-11T12:06:26","modified_gmt":"2026-03-11T11:06:26","slug":"copper-alzheimer","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=12538&lang=en","title":{"rendered":"Copper-Amylin-Alzheimer-EN"},"content":{"rendered":"\t\t
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Roles of copper and amylin in the development of Alzheimer’s disease<\/strong><\/p>\n

 <\/p>\n

\u00a0Nicolas VITALE<\/span><\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Les \u00e9quipes<\/a>  ⇨  Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Presentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/p>

Although Alzheimer’s disease has a major societal impact and cost in our aging societies, very little progress has been made from a therapeutic point of view, despite major efforts in clinical research. This apparent paradox may stem from a still partial understanding of the molecular mechanisms that lead to this neurodegenerative pathology. Thus, it now seems obvious to consider Alzheimer’s disease not only under its aggregative aspect, but to consider it under a multifactorial aspect.<\/p>

We will try to shed some original light on the subject by focusing on an alteration in the homeostasis of metals in the brain, which potentially promotes neuronal degeneration. Among these metals, copper, whose level could be reduced in neurons, binds to amyloid beta and is also capable of catalyzing the production of reactive oxygen species toxic to neurons.<\/p>

We seek to better understand the role of deregulated brain copper levels in the development of Alzheimer’s disease, focusing on neuronal function. The use of novel copper sensors and shuttles capable of capturing copper from amyloid plaques and delivering it to neurons represent valuable tools to better understand the implications of deregulated copper homeostasis and have potential applications in restoring copper homeostasis in Alzheimer’s disease. In parallel, we are studying the potential synergistic role of excess amylin release in diabetic patients who have a 2-3 fold increased risk of developing Alzheimer’s disease.<\/p>

\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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T<\/b>eam members<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"David\"<\/figure>

David Schmitt<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Stef\"<\/a><\/figure>

St\u00e9phane Gasman<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Nico\"<\/a><\/figure>

Nicolas Vitale<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"AMH\"<\/a><\/figure>

Anne-Marie Haeberl\u00e9<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Claudine Boissier<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Pr Peter Faller: <\/strong>Institut de Chimie et Universit\u00e9 de Strasbourg<\/p>

Dr Christelle Hureau<\/strong>: Laboratoire de Chimie de Coordination du CNRS, Toulouse<\/p>

Dr Thomas Pr\u00e9at<\/strong>\u00a0: Laboratoire Plasticit\u00e9 du Cerveau du CNRS, ESPCI, Paris<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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S<\/b>elected publications<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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– Okafor M, Faller P, Vitale N. Cell-specific copper dyshomeostasis mechanism in Alzheimer’s disease. Transl Neurodegener.<\/strong> 2025 Aug 22;14(1):42.<\/p>

– Okafor M, Champomier O, Raibaut L, Ozkan S, El Kholti N, Ory S, Chasserot-Golaz S, Gasman S, Hureau C, Faller P, Vitale N. Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes. Front Mol Biosci.<\/strong> 2024 Apr 5;11:1355963.<\/p>

– Okafor M, Schmitt D, Gasman S, Raibaut L, Hureau C, Faller P, Vitale N. Next-generation Cu(II) selective peptide shuttles prevent Cu(A\u03b2)-induced toxicity and microglial activation in organotypic hippocampal slices. 2024. bioRxiv<\/strong>, 10.1101\/2024.09.04.611242.<\/p>

– Okafor M, Gonzalez P, Ronot P, El Masoudi I, Boos A, Ory S, Chasserot-Golaz S, Gasman S, Raibaut L, Hureau C, Vitale N, Faller P. Development of Cu(ii)-specific peptide shuttles capable of preventing Cu-amyloid beta toxicity and importing bioavailable Cu into cells. Chem Sci.<\/strong> 2022, 13(40):11829-11840.<\/p>

– Falconea E, Okafora N, Vitale N, Raibauta L, Soura A, Faller P. Extracellular Cu2+ pools and their detection: from current knowledge to next-generation probes. Coord. Chem. Rev.<\/strong> 2021, (433) 213727.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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The Conversation: Les m\u00e9taux sont-ils le cha\u00eenon manquant pour comprendre la maladie d\u2019Alzheimer ?<\/a><\/p>

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  ⇨  Les \u00e9quipes  ⇨  Trafic membranaire intracellulaire dans les syst\u00e8mes nerveux et neuroendocrines Presentation Although Alzheimer’s disease has a major societal impact and cost in our aging societies, very little progress has been made from a therapeutic point of view, despite major efforts in clinical research. This apparent paradox may stem from a still partial understanding of the […]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":10579,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-12538","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nCopper-Amylin-Alzheimer-EN - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"The proton gradient generated by the V-ATPase is directly used by specific transporters to load neurotransmetters and chemical messenger molecules into secretory vesicles. However an additional more direct role for V-ATPases has been proposed in membrane fusion, although the precise molecular mechanisms involves have remained a mistery\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=12538&lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Copper-Amylin-Alzheimer-EN - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"The proton gradient generated by the V-ATPase is directly used by specific transporters to load neurotransmetters and chemical messenger molecules into secretory vesicles. 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