{"id":12521,"date":"2023-11-03T11:11:18","date_gmt":"2023-11-03T10:11:18","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=12521"},"modified":"2026-03-08T11:20:25","modified_gmt":"2026-03-08T10:20:25","slug":"lipids-and-membrane-fusion","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=12521&lang=en","title":{"rendered":"Membrane contact sites and regulated exocytosis"},"content":{"rendered":"\t\t
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Role of membrane contact sites in calcium and lipid dynamics during regulated exocytosis<\/strong><\/a><\/p>\n

Sylvette CHASSEROT-GOLAZ, Nicolas VITALE<\/span><\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\t\t<\/span>\n<\/a>  ⇨  Teams<\/a>  ⇨  Intracellular membrane trafficking in the nervous and neuroendocrine systems<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Presentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"\"<\/p>

Regulated exocytosis is a complex process that enables the release of informative molecules stored in dedicated vesicles to enable cell-to-cell communication in multicellular organisms. This process begins with vesicle genesis, continues with vesicle transport, culminating in vesicle docking to the plasma membrane and fusion in response to elevated cytosolic calcium, allowing the release of vesicle contents outside the cell, and ends with the recycling of granular components by compensatory endocytosis. Numerous proteins playing a key role in these processes have been identified in recent decades. Although this process involves specific membrane compartments, the role of lipids, major constituents of membranes, and their dynamics between these compartments, remain much less understood.<\/p>

The aim of this project is to understand the role of contact sites between the endoplasmic reticulum,<\/strong> secretory granules and the plasma membrane<\/strong> in regulating the cycle of exocytosis and endocytosis. In particular, we are studying the dynamics of calcium in the vicinity of exocytosis sites, and the contribution of different forms of phosphatidic acid (PA) during the various stages of exocytosis and their dynamics within these inter-organelle contact sites.<\/p>

To answer these questions, we are using a molecular toolbox dedicated to the study of PA<\/strong>, based on optogenetic approaches and the use of new forms of PA synthesis that can be activated on demand on the basis of click chemistry.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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\"sylvette\"<\/figure>

Sylvette Chasserot-Golaz<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Emeline\"<\/a><\/figure>

Emeline Tanguy<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Nico\"<\/a><\/figure>

Nicolas Vitale<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Stef\"<\/a><\/figure>

St\u00e9phane Gasman<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Alexander Wolf<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"AMH\"<\/a><\/figure>

Anne-Marie Haeberl\u00e9<\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Claudine Boissier<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\"Anonyme-90x110\"<\/figure>

Sebahat Ozkan<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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C<\/b>ollaborations<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Pr Mait\u00e9 Montero<\/strong> : DC2N laboratory, Rouen
Pr Pierre-Yves Renard<\/strong> : CARMEN laboratory, Rouen
Dr Johann B\u00f6hm<\/strong> : IGBMC, Strasbourg
Dr Guillaume Drin<\/strong> : IPMC, Valbonne
Dr Oussama El Far<\/strong> : UNIS Laboratory, Marseille
Dr Franck Delavoie<\/strong> : University of Toulouse III, Toulouse<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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S<\/b>elected publications<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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– Streit L, Delavoie F, Wolf A, Royer C, Haeberl\u00e9 AM, Hugel S, Gasman S, Vitale N, Chasserot-Golaz S. Endoplasmic reticulum membrane contact sites coordinate exocytic site assembly and activity in neuroendocrine cells. BioRxiv<\/strong> 2026 https:\/\/doi.org\/10.64898\/2026.02.04.703764<\/p>

– Schlichter A, Wolf A, Ferrand T, Cocq A, Riachy L, Vertueux S, Beauvais B, Courvalet M, Henry PJ, Tanguy E, Gonzales L, Ferlet R, Laguerre F, Decraene C, Pellissier A, Sebban M, Sabot C, Jeandel L, Cianf\u00e9rani S, Strub JM, B\u00e9nard M, Flon V, Peulon-Agasse V, Cardinael P, Ory S, Gasman S, Renard PY, Montero-Hadjadje M, Vitale N, Balieu S. Designing New Natural-Mimetic Phosphatidic Acid: A Versatile and Innovative Synthetic Strategy for Glycerophospholipid Research. Angew Chem Int Ed Engl<\/strong> 2025 Jul 8:e202510412.<\/p>

– Tanguy E, Cost\u00e9 de Bagneaux P, Kassas N, Ammar MR, Wang Q, Haeberl\u00e9 AM, Raherindratsara J, Fouillen L, Renard PY, Montero-Hadjadje M, Chasserot-Golaz S, Ory S, Gasman S, Bader MF and Vitale N. Mono- and poly-unsaturated phosphatidic acid regulate distinct steps of regulated exocytosis in neuroendocrine cells. Cell Reports<\/strong> 2020, 32(7):108026.<\/p>

– Kassas N, Tanguy E, Thahouly T, Fouillen L, Heintz D, Chasserot-Golaz S, Bader MF, Grant NJ, Vitale N. Comparative characterization of phosphatidic acid sensors and their localization during frustrated phagocytosis. J Biol Chem<\/strong> 2017, 292: 4266-4279<\/p>

– Gabel M, Delavoie F, Demais V, Royer C, Bailly Y, Vitale N, Bader MF, Chasserot-Golaz S. Annexin A2-dependent actin bundling promotes secretory granule docking to the plasma membrane and exocytosis.
J Cell Biol <\/strong>2015 Aug 31;210(5):785-800

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CNRS: Quand les lipides r\u00e9v\u00e8lent leurs secrets<\/a><\/p>

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  ⇨  Teams  ⇨  Intracellular membrane trafficking in the nervous and neuroendocrine systems Presentation Regulated exocytosis is a complex process that enables the release of informative molecules stored in dedicated vesicles to enable cell-to-cell communication in multicellular organisms. This process begins with vesicle genesis, continues with vesicle transport, culminating in vesicle docking to the plasma membrane and fusion in […]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":10579,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-12521","page","type-page","status-publish","hentry","entry"],"yoast_head":"\nMembrane contact sites and regulated exocytosis - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"Exocytosis is a multistep process allowing release of informative molecules stores in dedicated secretory organelles for chemical cell-to-cell communication. Even if this process involves specific membrane compartments, the role of lipids the main constituents of membrane remains poorly understood\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=12521&lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Membrane contact sites and regulated exocytosis - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"Exocytosis is a multistep process allowing release of informative molecules stores in dedicated secretory organelles for chemical cell-to-cell communication. 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