{"id":10643,"date":"2023-10-20T15:00:44","date_gmt":"2023-10-20T13:00:44","guid":{"rendered":"https:\/\/inci.neuro.unistra.fr\/?page_id=10643"},"modified":"2024-03-19T07:26:36","modified_gmt":"2024-03-19T06:26:36","slug":"circadian-clock-sleep-and-homeostatic-plasticity-in-mood-disorders","status":"publish","type":"page","link":"https:\/\/inci.neuro.unistra.fr\/?page_id=10643&lang=en","title":{"rendered":"Circadian clock, sleep and homeostatic plasticity in mood disorders"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"10643\" class=\"elementor elementor-10643\">\n\t\t\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-a3f19b4 elementor-section-full_width elementor-section-content-top elementor-section-stretched elementor-reverse-mobile elementor-section-height-default elementor-section-height-default\" data-id=\"a3f19b4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-3463775\" data-id=\"3463775\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-56d64da elementor-widget__width-initial elementor-widget elementor-widget-wp-widget-media_image\" data-id=\"56d64da\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-media_image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1.jpg\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1500\" height=\"500\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1.jpg\" class=\"image wp-image-20877  attachment-full size-full\" alt=\"\" style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1.jpg 1500w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1-300x100.jpg 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1-1024x341.jpg 1024w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/horloge-circadienne-plasticite-homeostatique-trouble-humeur-1500x500-1-768x256.jpg 768w\" sizes=\"(max-width: 1500px) 100vw, 1500px\" \/><\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-73ae7ae\" data-id=\"73ae7ae\" data-element_type=\"column\" data-e-type=\"column\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-dee695e elementor-widget-mobile__width-inherit elementor-widget elementor-widget-wp-widget-text\" data-id=\"dee695e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-text.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"textwidget\"><p><a href=\"#bgn\"><strong class=\"titre-horloge-circadienne-sommeil\"><b>Circadian clock, sleep and homeostatic plasticity in mood disorders<\/b><\/strong><\/a><\/p>\n<p><em><strong>Tsvetan SERCHOV<\/strong><\/em><\/p>\n<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-a14a87e elementor-section-full_width elementor-section-content-top elementor-section-height-default elementor-section-height-default\" data-id=\"a14a87e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ee3d8f5\" data-id=\"ee3d8f5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45cadd2 elementor-widget elementor-widget-image\" data-id=\"45cadd2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1000\" height=\"70\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png\" class=\"attachment-full size-full wp-image-20857\" alt=\"\" srcset=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1.png 1000w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1-300x21.png 300w, https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/03\/fleche-bas-HCS-PHTH-1000x70-1-768x54.png 768w\" sizes=\"(max-width: 1000px) 100vw, 1000px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b0a0437 elementor-section-height-min-height elementor-section-content-top elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-items-middle\" data-id=\"b0a0437\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4f39117\" data-id=\"4f39117\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-651074f elementor-widget elementor-widget-html\" data-id=\"651074f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<span id=\"bgn\"><\/span>\n<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=95&lang=en\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/02\/home.png\"><\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=95&lang=en#equipes\">Teams<\/a>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;<a href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=20922&lang=en\">Sleep, Clock, Light & NeuroPsychiatry<\/a>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-dd50115 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"dd50115\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5e1c3b9\" data-id=\"5e1c3b9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-11e5510 elementor-widget elementor-widget-heading\" data-id=\"11e5510\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Presentation<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-e963e95 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e963e95\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3c788c6\" data-id=\"3c788c6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ae698f1 elementor-widget elementor-widget-text-editor\" data-id=\"ae698f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Mood disorders are among the most commonly diagnosed disabling mental diseases. Despite the numerous pathophysiological hypotheses, elucidating the neurobiological basis of depression remains one of the foremost challenges in modern psychiatry.<\/p><p>Disruptions of sleep and circadian rhythm are associated with the development of various psychiatric diseases. Chronotherapies, which include a variety of strategies that modulate biological clock and sleep-wake cycle, such as sleep deprivation and light therapy, are alternative treatments for mood disorders. Our previous work demonstrates that the rapid antidepressant effects of acute sleep deprivation depend on enhanced glutamatergic signaling. However, the involvement of the circadian clock in the antidepressant action and the pathophysiology of mood disorders is not yet well understood.<\/p><p>Using a combination of molecular biological methods, in vivo electrophysiology and complex behavioural analyses, we study the molecular and cellular mechanism of action of rapid antidepressant treatments and neurobiology of mood disorders. In particularly we aim:<\/p><ul><li>To investigate the role of the circadian clock in the pathophysiology and treatment of depression and bipolar disorder<\/li><li>To characterize the crosstalk between circadian and sleep homeostatic mechanisms on glutamatergic signaling in mood regulation<\/li><li>To study the impact of light in the antidepressant action of acute sleep deprivation<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-3b929da elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"3b929da\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-e3c6d65\" data-id=\"e3c6d65\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f6a8ad7 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"f6a8ad7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>R<\/b>esearchers<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-d45f3d0 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d45f3d0\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-0d2fee0\" data-id=\"0d2fee0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-b290ea1 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b290ea1\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-inner-column elementor-element elementor-element-9bf768b\" data-id=\"9bf768b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-dbcc428 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"dbcc428\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Tsvetan.Serchov-90x110-1-qe2tsbqc4tkxvkx6knvkl93hufbh8s25gg5la870u8.jpg\" title=\"Tsvetan.Serchov-90&#215;110\" alt=\"Tsvetan.Serchov-90x110\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Tsvetan Serchov<\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-9e52bc3\" data-id=\"9e52bc3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-fef9cae\" data-id=\"fef9cae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-9080de9 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"9080de9\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7ec91b4\" data-id=\"7ec91b4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-9f60401 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"9f60401\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>P<\/b>ostdoctoral fellow \/ Ph.D. students<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c59f3f3 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c59f3f3\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-392d227\" data-id=\"392d227\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-927a64d elementor-widget elementor-widget-text-editor\" data-id=\"927a64d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<figure id=\"attachment_17041\" aria-describedby=\"caption-attachment-17041\" style=\"width: 128px\" class=\"wp-caption alignleft\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/01\/Xinling.Wang-214x300-1.jpg\"><img decoding=\"async\" class=\"wp-image-17041\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2024\/01\/Xinling.Wang-214x300-1.jpg\" alt=\"\" width=\"128\" height=\"180\" \/><\/a><figcaption id=\"caption-attachment-17041\" class=\"wp-caption-text\"><span class=\"legende\">Xinling Wang<\/span> (postdoctoral fellow)<\/figcaption><\/figure><p>My project title is: \u00ab\u00a0The link between circadian genes and dopaminergic system mediates mood transitions\u00a0\u00bb.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-9ed4cc4 elementor-section-content-top elementor-section-stretched elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9ed4cc4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1c2924a\" data-id=\"1c2924a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-a212be4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a212be4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-63598bb\" data-id=\"63598bb\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b70c3a0 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"b70c3a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Wilg.Gardner-90x110-1-qgnpwl1m7c15jm9bp5exfp0nq4wy7x3nz07curbnr4.jpg\" title=\"Wilg.Gardner-90&#215;110\" alt=\"Wilg.Gardner-90x110\" loading=\"lazy\" \/><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\">Wilf Gardner <i>(postdoctoral fellow)<\/i><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b6eec7e\" data-id=\"b6eec7e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-75a9e0f elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"75a9e0f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/David.Sarrazin-214x300-1.jpg\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/David.Sarrazin-214x300-1-qgd78ejujglxzgypcvyjrcyqevqcygvti0u1vxunls.jpg\" title=\"David.Sarrazin-214&#215;300\" alt=\"David.Sarrazin-214x300\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h2 class=\"elementor-image-box-title\"><a href=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/12\/David.Sarrazin-214x300-1.jpg\">David Sarrazin <i>(Ph. D. student)<\/i><\/a><\/h2><\/div><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-7217bbb elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"7217bbb\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1786fae\" data-id=\"1786fae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bb3a9d elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"8bb3a9d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>C<\/b>ollaborators<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-6f64553 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6f64553\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2cb1ff4\" data-id=\"2cb1ff4\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-5590a44 elementor-widget elementor-widget-text-editor\" data-id=\"5590a44\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<ul><li>Prof. Dr. Claus Normann <em>(Psychiatry, Uniklinik Freiburg)<\/em><\/li><li>Prof. Dr. Bernd Fakler<em> (Physiology, University Freiburg)<\/em><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-d9579ed elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"d9579ed\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7be1429\" data-id=\"7be1429\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4bcc9e1 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"4bcc9e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>M<\/b>ethodological approaches<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-39b7eb5 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"39b7eb5\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-36b884f\" data-id=\"36b884f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d12794d elementor-widget elementor-widget-text-editor\" data-id=\"d12794d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Genetically modified mouse models<br \/>Quantitative PCR, SDS-PAGE, Western blotting, Immunohystochemistry<br \/>Classical behavioral tests and complex automatic behavioral modeling and analyses via IntelliCage<br \/>In Vivo Electrophysiology: LFP and EEG <em>(sleep)<\/em> recordings<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-28ee702 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"28ee702\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8974a73\" data-id=\"8974a73\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6140e70 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"6140e70\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>F<\/b>unding<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-2c5d9ca elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2c5d9ca\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-121075f\" data-id=\"121075f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3084b04 elementor-widget elementor-widget-text-editor\" data-id=\"3084b04\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Fondation pour la Recherche Medical (<a href=\"https:\/\/www.frm.org\/\" target=\"_blank\" rel=\"noopener\">FRM<\/a>)<br \/>University of Strasbourg Institute for Advanced Studies (<a href=\"https:\/\/www.usias.fr\/\" target=\"_blank\" rel=\"noopener\">USIAS<\/a>)<br \/>German Research Foundation (<a href=\"https:\/\/www.dfg.de\/en\/\" target=\"_blank\" rel=\"noopener\">DFG<\/a>)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-493db0f elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"493db0f\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-69ba7a0\" data-id=\"69ba7a0\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-df514df elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"df514df\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-bddcb41\" data-id=\"bddcb41\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-919a31e elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"919a31e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.frm.org\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-frm-244x200-1-q37grwjg8cyaatrqowgslu4cculfmy2wkuqh1w0xz4.jpg\" title=\"logo-frm-244&#215;200\" alt=\"logo-frm-244x200\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-c58bc9d\" data-id=\"c58bc9d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e9a48b7 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"e9a48b7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.usias.fr\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-usias-244x200-1-q37grzcysv259nnn8foobbeq507ja1e3l8oxhpwrgg.jpg\" title=\"logo-usias-244&#215;200\" alt=\"logo-usias-244x200\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-d6bc67f\" data-id=\"d6bc67f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b6dd82 elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"2b6dd82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.dfg.de\/en\/\" target=\"_blank\" tabindex=\"-1\"><img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo-dfg-244x200-1-q37grtpxnuufbzvu5d8wwctykozbzurpkgs0m254hs.jpg\" title=\"logo-dfg-244&#215;200\" alt=\"logo-dfg-244x200\" loading=\"lazy\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-29ed2da\" data-id=\"29ed2da\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2b65245 elementor-widget elementor-widget-image\" data-id=\"2b65245\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/neurostra.unistra.fr\/\" target=\"_blank\">\n\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/logo_neurostra-228x105-1-qgn8ynjrhh2iikh62uae8kggpfi2xfjf8o0ogz4jr4.jpg\" title=\"logo_neurostra-228&#215;105\" alt=\"logo_neurostra-228x105\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-20 elementor-inner-column elementor-element elementor-element-b785fd6\" data-id=\"b785fd6\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d43a549 elementor-widget elementor-widget-image\" data-id=\"d43a549\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/elementor\/thumbs\/Logo_AAP_Idex-735x116-1-qgn8ynjrhh2jjecdsn80nx8yq4fahq4zdcakkmgao0.png\" title=\"Logo_AAP_Idex-735&#215;116\" alt=\"Logo_AAP_Idex-735x116\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f817ce5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f817ce5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-fa4f5ba\" data-id=\"fa4f5ba\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-d5553c2 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"d5553c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div 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publications<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4e05ae7\" data-id=\"4e05ae7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-132611d elementor-position-top elementor-widget elementor-widget-image-box\" data-id=\"132611d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/scholar.google.com\/citations?user=jF5-u_UAAAAJ&#038;hl=en\" target=\"_blank\" tabindex=\"-1\"><img loading=\"lazy\" decoding=\"async\" width=\"166\" height=\"63\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/google-scholar-166x63-1.png\" class=\"attachment-full size-full wp-image-13679\" alt=\"\" \/><\/a><\/figure><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7bb08e2 elementor-hidden-desktop elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7bb08e2\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7fcf224\" data-id=\"7fcf224\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0ba54a1 elementor-widget elementor-widget-image\" data-id=\"0ba54a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/scholar.google.com\/citations?user=jF5-u_UAAAAJ&#038;hl=en\" target=\"_blank\">\n\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"166\" height=\"63\" src=\"https:\/\/inci.neuro.unistra.fr\/wp-content\/uploads\/2023\/11\/google-scholar-166x63-1.png\" class=\"attachment-full size-full wp-image-13679\" alt=\"\" \/>\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-764b76e elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"764b76e\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-924b203\" data-id=\"924b203\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd98b63 elementor-widget-divider--view-line_icon elementor-view-default elementor-widget-divider--element-align-center elementor-widget elementor-widget-divider\" data-id=\"fd98b63\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon elementor-divider__element\">\n\t\t\t\t\t<i aria-hidden=\"true\" class=\"fas fa-caret-up\"><\/i><\/div>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-0bf7fb2 elementor-section-content-bottom elementor-section-boxed elementor-section-height-default elementor-section-height-default elementor-invisible\" data-id=\"0bf7fb2\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;animation&quot;:&quot;fadeInLeft&quot;,&quot;animation_delay&quot;:500}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-narrow\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-af1a0ad\" data-id=\"af1a0ad\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-af1c101 elementor-widget elementor-widget-wp-widget-custom_html\" data-id=\"af1c101\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"wp-widget-custom_html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"textwidget custom-html-widget\"><span class=\"titre\"><b>S<\/b>elected publicatons<\/span><\/div>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-section elementor-top-section elementor-element elementor-element-6e1ee01 elementor-section-content-top elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6e1ee01\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 1000 100\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0,6V0h1000v100L0,6z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a1032be\" data-id=\"a1032be\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8543829 elementor-widget elementor-widget-text-editor\" data-id=\"8543829\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Van Calker D,<strong> Serchov T*<\/strong>. <em>(2021)<\/em> The \u00ab\u00a0Missing Heritability\u00a0\u00bb-Problem in Psychiatry: Is the interaction of Genetics, Epigenetics and Transposable Elements a potential solution? <strong>Neurosci Biobehav Rev<\/strong>. S0149-7634 (21) 00134-2. doi: 10.1016\/j.neubiorev. 2021.03.019<\/p><p>Casarotto PC, Girych M, Fred SM, Kovaleva V, Moliner R, Enkavi G, Biojone C, Cannarozzo C, Sahu MP, Kaurinkoski K, Brunello CA, Steinzeig A, Winkel F, Patil S, Vestring S, <strong>Serchov T<\/strong>, Diniz CRAF, Laukkanen L, Cardon I, Antila H, Rog T, Piepponen TP, Bramham CR, Normann C, Lauri SE, Saarma M, Vattulainen I, Castr\u00e9n E. (2021) Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell. 184<em>(5)<\/em>:1299-1313.e19. doi: 10.1016\/j.<strong>cell<\/strong>.2021.01.034.<\/p><p>Sun L, Verkaik-Schakel RK, Biber K, Pl\u00f6sch T, <strong>Serchov T*<\/strong> <em>(2021)<\/em> Antidepressant treatment is associated with epigenetic alterations of Homer1 promoter in a mouse model of chronic depression <strong>J Affect Disord<\/strong>. 279:501-509, doi: 10.1016\/j.jad.2020.10.040.<\/p><p><strong>Serchov T*<\/strong>, Schwarz I, Theiss A, Sun L, Holz A, D\u00f6br\u00f6ssy MD, Schwarz MK, Normann C, Biber K, van Calker D.<em> (2019)<\/em> Enhanced adenosine A1 receptor and Homer1a expression in hippocampus modulates the resilience to stress-induced depression-like behavior. <strong>Neuropharmacology<\/strong>. 107834. doi: 10.1016\/j.neuropharm.2019.<\/p><p>Holz A, M\u00fclsch F, Schwarz MK, Hollmann M, D\u00f6br\u00f6ssy MD, Coenen VA, Bartos M, Normann C, Biber K, van Calker D, <strong>Serchov T*<\/strong>. <em>(2019)<\/em> Enhanced mGlu5 Signaling in Excitatory Neurons Promotes Rapid Antidepressant Effects via AMPA Receptor Activation. <strong>Neuron<\/strong>. pii: S0896-6273(19)30637-3. doi: 10.1016\/j.neuron.2019.07.011. <\/p><p>Van Calker D, Biber K, Domschke K, <strong>Serchov T*<\/strong>. <em>(2019)<\/em> The Role of Adenosine Receptors in Mood and Anxiety Disorders.<strong> J Neurochem<\/strong>. doi: 10.1111\/jnc.14841. <\/p><p><strong>Serchov T<\/strong>, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M, Jacobson KA, de Bartolomeis A, Normann C, Biber K, van Calker D.<em> (2015)<\/em> Increased Signaling via Adenosine A1 Receptors, Sleep Deprivation, Imipramine, and Ketamine Inhibit Depressive-like Behavior via Induction of Homer1a. <strong>Neuron<\/strong>. 87(3):549-62. doi: 10.1016\/j.neuron.2015.07.010.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-fdff935 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"fdff935\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7a5359f\" data-id=\"7a5359f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6c1b73d elementor-widget elementor-widget-spacer\" data-id=\"6c1b73d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Teams&nbsp;&nbsp;&#8680;&nbsp;&nbsp;Sleep, Clock, Light &#038; NeuroPsychiatry Presentation Mood disorders are among the most commonly diagnosed disabling mental diseases. Despite the numerous pathophysiological hypotheses, elucidating the neurobiological basis of depression remains one of the foremost challenges in modern psychiatry. Disruptions of sleep and circadian rhythm are associated with the development of various psychiatric diseases. Chronotherapies, which include [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":20922,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_post_layout":"","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"default","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":0,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"default","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"default","ocean_display_footer_bottom":"default","ocean_custom_footer_template":"0","omw_enable_modal_window":"enable","footnotes":""},"class_list":["post-10643","page","type-page","status-publish","hentry","entry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Circadian clock, sleep and homeostatic plasticity in mood disorders - Institut des Neurosciences Cellulaires et Int\u00e9gratives<\/title>\n<meta name=\"description\" content=\"Mood disorders are among the most commonly diagnosed disabling mental diseases. Despite the numerous pathophysiological hypotheses, elucidating the neurobiological basis of depression remains one of the foremost challenges in modern psychiatry\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/inci.neuro.unistra.fr\/?page_id=10643&lang=en\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Circadian clock, sleep and homeostatic plasticity in mood disorders - Institut des Neurosciences Cellulaires et Int\u00e9gratives\" \/>\n<meta property=\"og:description\" content=\"Mood disorders are among the most commonly diagnosed disabling mental diseases. 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